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scpA

part of the condensin complex, chromosomal origin condensation and segregation

Locus

BSU_23220

Isoelectric point

4.79

Molecular weight

29.46 kDa

Protein length

251 aa Sequence Blast

Gene length

756 bp Sequence Blast

Function

segregation of replication origins

Product

DNA segregation and condensation protein

Essential

yes

Synonyms

ypuG

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Information processing → Genetics → DNA condensation/ segregation

Groups of genes → Essential genes

Gene

Coordinates

2,425,831 2,426,586

Phenotypes of a mutant

essential PubMed

scpA mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth PubMed

The protein

Protein family

scpA family (single member, according to UniProt)

Structure

3ZGX (complex between the head domain of Smc (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of ScpA) PubMed

4I98 (complex between ScpA (aa 1-160)-ScpB (aa 1-183) PubMed

Localization

nucleoid (Multiple) PubMed

the condensin (Smc)₂-ScpA-ScpB complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on ParA PubMed*the condensin (Smc)2-ScpA-ScpB complex is loaded by ParB to parS centromeric sites adjacent to the replication origin, travels then from the origin to the terminus at rates >50 kb per minute PubMed

Expression and Regulation

Operons

Genes

scpA-scpB-ypuI

Description

PubMed

Regulatory mechanism

stringent response: negative regulation, in stringent response

Regulation

RelA dependent downregulation (Class I) during stringent response PubMed

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Biological materials

Mutant

MGNA-A104 (ypuG::erm), available at the NBRP B. subtilis, Japan

References

Reviews

Original publications