SubtiBank SubtiBank
resA
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resA

extracytoplasmic thioredoxin, cytochrome c biogenesis, reduces disulfide bonds in apo-cytochrome prior to the attachment of heme
Locus
BSU_23150
Isoelectric point
8.37
Molecular weight
20.76 kDa
Protein length
179 aa Sequence Blast
Gene length
540 bp Sequence Blast
Function
cytochrome c biogenesis
Product
extracytoplasmic thioredoxin
Essential
no
Synonyms
ypxA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Electron transport and ATP synthesis → Respiration → Respiration/ other
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    2,420,804 → 2,421,343

    Phenotypes of a mutant

  • essential according to Kobayashi et al., but inactivation of resA was reported by Erlendsson et al. and by Meeske et al.
  • inactivation of resA reduces sporulation efficiency to 45.6% that of wild type cells; delayed entry into sporulation PubMed

    • The protein

    Protein family

  • Thioredoxin family (according to UniProt)

    • Paralogous protein(s)

  • StoA, YneN

    • Domains

  • Thioredoxin domain (aa 36-174) (according to UniProt)

    • Structure

  • 3C73

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    rluB-resA-resB-resC-resD-resE
    Description
    PubMed
    view in new tab

    Genes
    resA-resB-resC-resD-resE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • ResD: activation, PubMed, in ResD regulon
  • PhoP: activation, PubMed, in PhoP regulon
  • CcpA: repression, PubMed, in CcpA regulon

    • Regulation

  • expressed under anaerobic conditions (ResD) PubMed
    • view in new tab

    Biological materials

    Mutant

  • BKE23150 (ΔresA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC, downstream forward: _UP4_ATAAAACCCGGAGAGACTTC
  • BKK23150 (ΔresA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC, downstream forward: _UP4_ATAAAACCCGGAGAGACTTC

    • References

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