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patB
function
biosynthesis of methionine
product
cystathione-beta-lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]Gene
Coordinates
3,228,778 3,229,941
The protein
Catalyzed reaction/ biological activity
H2O + L,L-cystathionine --> L-homocysteine + NH4+ + pyruvate (according to UniProt)Protein family
[SW|class-II pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)[SW|Cofactors]
PLP (according to UniProt)Structure
[PDB|3T32] (from ''B. anthracis'', 46% identity, 75% similarity)Expression and Regulation
Operons
genes
[gene|11B54D438CDD2EAA4A87A6B99851A3B123EA4A1F|patB]
description
[Pubmed|9274030]
Biological materials
Mutant
1A952 ( ''patB''::''cat''), [Pubmed|15760717], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A952&Search=1A952 BGSC]BKE31440 ([gene|11B54D438CDD2EAA4A87A6B99851A3B123EA4A1F|patB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGTTACCCCCTCATG, downstream forward: _UP4_TAAATATAGCTGTAAACGCCBKK31440 ([gene|11B54D438CDD2EAA4A87A6B99851A3B123EA4A1F|patB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTGTTACCCCCTCATG, downstream forward: _UP4_TAAATATAGCTGTAAACGCCReferences
