SubtiBank SubtiBank
hemC
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

hemC

hydroxymethylbilane synthase
Locus
BSU_28150
Isoelectric point
5.09
Molecular weight
34.68 kDa
Protein length
314 aa Sequence Blast
Gene length
945 bp Sequence Blast
Function
heme biosynthesis
Product
hydroxymethylbilane synthase
Essential
no
E.C.
2.5.1.61
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
Loading

Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of heme/ siroheme

    • Gene

    Coordinates
    2,875,951 → 2,876,895

    The protein

    Catalyzed reaction/ biological activity

  • H2O + 4 porphobilinogen --> hydroxymethylbilane + 4 NH4+ (according to UniProt)

    • Protein family

  • HMBS family (single member, according to UniProt)

    • Structure

  • 4MLQ (from Bacillus megaterium, 70% identity) PubMed

    • Expression and Regulation

    Operons

    Count
    2
    Genes
    hemA-hemX-hemC-hemD-hemB-hemL
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • PerR: repression, PubMed, in PerR regulon

    • Regulation

  • induced by hydrogen peroxide (PerR) PubMed
    • view in new tab

    Biological materials

    Mutant

  • BKE28150 (ΔhemC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTCTTTCCTCCCGAATC, downstream forward: _UP4_CGTGTAAAACGGGAGCTTGA
  • BKK28150 (ΔhemC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTCTTTCCTCCCGAATC, downstream forward: _UP4_CGTGTAAAACGGGAGCTTGA

    • References

    Reviews

    Loading

    Original Publications

    Loading