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fliR
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fliR

part of the flagellar type III export apparatus (flagellar Type III secretion system), part of the CORE complex required for flagellum and nanotube assembly
Locus
BSU_16370
Isoelectric point
5.58
Molecular weight
28.45 kDa
Protein length
259 aa Sequence Blast
Gene length
780 bp Sequence Blast
Function
flagellum and nanotube assembly
Product
part of the type III CORE export apparatus
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Protein synthesis, modification and degradation → Protein secretion
  • Lifestyles → Exponential and early post-exponential lifestyles → Motility and chemotaxis → Flagellar proteins
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    1,705,820 1,706,599

    Phenotypes of a mutant

  • no secretion of FlgM, permanent inhibition of SigD PubMed
  • deficient in both nanotube production and the associated intercellular molecular trafficking PubMed

    • The protein

    Protein family

  • FliR/MopE/SpaR family (single member, according to UniProt)

    • Structure

  • 6F2D (the FliP-FliQ-FliR complex of Salmonella typhimurium, 26% identity) PubMed

    • Localization

  • cell membrane (according to UniProt)
  • flagellum basal body (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigD: sigma factor, PubMed, in SigD regulon

    • Regulatory mechanism

  • Spo0A: repression, in Spo0A regulon
  • CodY: repression, in CodY regulon
  • DegU: regulation, in DegU regulon
  • SwrA: activation, in SwrA regulon

    • Regulation

  • see fla-che operon
    • view in new tab

    Genes
    flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigD: sigma factor, PubMed, in SigD regulon

    • Regulatory mechanism

  • Spo0A: repression, in Spo0A regulon
  • SwrA: activation, in SwrA regulon
  • CodY: repression, in CodY regulon
  • DegU: repression, in DegU regulon

    • Regulation

  • expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
    • view in new tab

    Biological materials

    Mutant

  • BKE16370 (fliR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTCAATAATTGAATTCATCT, downstream forward: _UP4_TTAGCATTGGTCGGTGTTTC
  • BKK16370 (fliR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GTCAATAATTGAATTCATCT, downstream forward: _UP4_TTAGCATTGGTCGGTGTTTC

    • References

    Reviews

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    Original publications

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