SubtiBank SubtiBank
fabL
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fabL

enoyl-acyl carrier protein reductase
Locus
BSU_08650
Isoelectric point
5.97
Molecular weight
27.03 kDa
Protein length
250 aa Sequence Blast
Gene length
753 bp Sequence Blast
Function
fatty acid biosynthesis
Product
enoyl-acyl carrier protein reductase
Essential
no
Synonyms
yfhR,ygaA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids
  • Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other

    • Gene

    Coordinates
    937,079 937,831

    The protein

    Catalyzed reaction/ biological activity

  • 2,3-saturated acyl-[ACP] + NADP+ --> (2E)-enoyl-[ACP] + H+ + NADPH (according to UniProt)

    • Protein family

  • Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)

    • Paralogous protein(s)

  • FabI:
  • YcdF:
  • YhdF:
  • YkvO:

    • Structure

  • 3OIC PubMed

    • Expression and Regulation

    Operons

    Genes
    fabL-sspE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigG: sigma factor, PubMed, in SigG regulon

    • Regulatory mechanism

  • SpoVT: repression, in SpoVT regulon
  • YfhP: repression, in YfhP regulon

    • Regulation

  • repressed by casamino acids PubMed
    • view in new tab

    Genes
    mutY-fabL-sspE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigG: sigma factor, PubMed, in SigG regulon

    • Regulatory mechanism

  • YfhP: repression, in YfhP regulon

    • Regulation

  • expression is constitutive throughout growth PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-C324 (yfhR::erm), available at the NBRP B. subtilis, Japan
  • BKE08650 (fabL::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG, downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG
  • BKK08650 (fabL::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG, downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG

    • References

    Reviews

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    Original Publications

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