SubtiBank SubtiBank
argC
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argC

N-acetyl-g-glutamyl-phosphate reductase
Locus
BSU_11190
Isoelectric point
5.17
Molecular weight
37.92 kDa
Protein length
346 aa Sequence Blast
Gene length
1038 bp Sequence Blast
Function
biosynthesis of arginine
Product
N-acetyl-g-glutamyl-phosphate reductase
Essential
no
E.C.
1.2.1.38
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of arginine

    • Gene

    Coordinates
    1,195,034 → 1,196,071

    The protein

    Catalyzed reaction/ biological activity

  • N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate --> H+ + N-acetyl-L-glutamyl 5-phosphate + NADPH (according to UniProt)

    • Protein family

  • NAGSA dehydrogenase family (single member, according to UniProt)

    • Structure

  • 1VKN (from Thermotoga maritima, 43% identity)

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    argC-argJ-argB-argD-carA-carB-argF
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • AhrC: repression, PubMed, in AhrC regulon
  • CodY: repression, PubMed, in CodY regulon
  • YlxR: regulation, PubMed, in YlxR regulon

    • Regulation

  • repressed by arginine (AhrC) PubMed
  • induced in the absence of YlxR PubMed
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    Biological materials

    Mutant

  • BKE11190 (ΔargC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAACAAGTTCACCCTCTT, downstream forward: _UP4_CCATAGAACGGGAGAGAATC
  • BKK11190 (ΔargC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAAAACAAGTTCACCCTCTT, downstream forward: _UP4_CCATAGAACGGGAGAGAATC

    • References

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