SubtiBank SubtiBank
ahpC
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ahpC

alkyl hydroperoxide reductase (small subunit)
Locus
BSU_40090
Isoelectric point
4.28
Molecular weight
20.48 kDa
Protein length
187 aa Sequence Blast
Gene length
564 bp Sequence Blast
Function
resistance against peroxide stres
Product
alkyl hydroperoxide reductase (small subunit)
Essential
no
E.C.
1.11.1.15
Synonyms
perR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
  • Groups of genes → Phosphoproteins → Phosphorylation on either a Ser, Thr or Tyr residue

    • Gene

    Coordinates
    4,118,950 → 4,119,513

    The protein

    Catalyzed reaction/ biological activity

  • [protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)

    • Protein family

  • peroxiredoxin family (according to UniProt)

    • Paralogous protein(s)

  • AhpA

    • Domains

  • Thioredoxin domain (aa 2-157) (according to UniProt)

    • Modification

  • phosphorylated on ser/ thr/ tyr PubMed

    • Structure

  • 1WE0 (from Amphibacillus xylanus, 78% identity, 88% similarity) PubMed

    • Additional information

  • belongs to the 100 most abundant proteins PubMed

    • Expression and Regulation

    Operons

    Genes
    ahpC-ahpF
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • PerR: repression, PubMed, in PerR regulon

    • Regulation

  • induced by H2O2 (PerR) PubMed
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    Biological materials

    Mutant

  • GP1730 ahpCF::mls trpC2 available at Jörg Stülkes lab
  • BKE40090 (ΔahpC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATGTATATTCCTCCTA, downstream forward: _UP4_GGTAAAATCTAAGGAGTGCA
  • BKK40090 (ΔahpC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAATGTATATTCCTCCTA, downstream forward: _UP4_GGTAAAATCTAAGGAGTGCA

    • References

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