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rnz
function
processing of CCA-less tRNA precursors
product
endoribonuclease Z
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
2,478,006 → 2,478,929
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule (according to UniProt)3' end maturation of tmRNA [Pubmed|25402410]Protein family
[SW|RNase] Z family (single member, according to UniProt)Structure
[PDB|2FK6] (in complex with tRNA-Thr) [Pubmed|22940585], [PDB|1Y44]Expression and Regulation
Operons
genes
[gene|C40C5D35ED53D343C8200248FCCB010BAB388054|rnz]-[gene|5189DF2F6144CD2429B5C01B1AD03BAE98307579|rpmGC]
description
[Pubmed|22383849]
labs
[SW|Ciaran Condon], IBPC, Paris, France [http://www.ibpc.fr/UPR9073/condon/index_en.html Homepage]References
Reviews
19215776,17599240,25878039,31464530 Original Publications
17005971,12941704,15654328,16518398,22940585,25402410,24022488,31003868 
