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dnaD
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dnaD

initiation of chromosome replication, part of the [SW|replisome]
locus
BSU_22350
pI
7.17
mw
27.49 kDa
protein length
232 aa Sequence Blast
gene length
699 bp Sequence Blast
function
[category|SW 3.1.1|DNA replication]
product
initiation of chromosome replication
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    2,345,433 → 2,346,131

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • [protein|C9FEE07601AD28B2651EB881A1D9B34D5082237C|DnaD]-mediated untwisting of the DNA stimulates [protein|C352560155F5B2E951B5059794D7B319C1A3AF2C|Nth] endonuclease activity at AP sites [Pubmed|21954439]
  • required for the assembly of the replicative helicase DnaC at the origin of replication [Pubmed|22821970]
  • interaction with DnaA inhibits the ability of DnaA to bind cooperatively to DNA [Pubmed|22821970]

    • Structure

  • [PDB|2C79] (N-terminal domain)

    • [SW|Localization]

  • Membrane-proximal (Spotty) [Pubmed|16479537]

    • Expression and Regulation

    Operons

    genes
    [gene|FBA7EAA70F5C9E76463B0C5F85D65D4314FFD40D|asnS]-[gene|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]-[gene|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth]-[gene|4B2A124B726393544A47791E5A5681F7B766A588|ypoC]
    description
    [Pubmed|22383849]
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    genes
    [gene|C9FEE07601AD28B2651EB881A1D9B34D5082237C|dnaD]-[gene|C352560155F5B2E951B5059794D7B319C1A3AF2C|nth]
    description
    [Pubmed|21954439]

    regulation

  • constitutively expressed [Pubmed|21954439]
    • view in new tab

    labs

  • [SW|Alan Grossman], MIT, Cambridge, MA, USA

    • References

    Reviews

  • 22797751,28075389

    • Original publications

  • 19707554,15686560,15186423,11585815,20122408,16479537,11222620,19968790,11679082,20587500,21097613,21954439,22821970,30285297,30534966