SubtiBank SubtiBank
abbA
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abbA

inhibitor of [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB] activity
locus
BSU_14120
pI
4.64
mw
7.56 kDa
protein length
65 aa Sequence Blast
gene length
198 bp Sequence Blast
function
inhibition of [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]
product
anti-repressor
essential
no
synonyms
ykzF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.7|Control of transcription factor (other than two-component system)]

    • Gene

    Coordinates
    1,485,118 1,485,315

    The protein

    Catalyzed reaction/ biological activity

  • inhibition of AbrB activity [Pubmed|18840696]

    • Structure

  • [PDB|2LZF] [Pubmed|24534728]

    • Expression and Regulation

    Operons

    genes
    [gene|A26502ADAC214D45A8F7F394587B0BDFBE7AF28E|ykuJ]-[gene|7FD784C885605F7FD27898BC9E83C28F21BE0E9D|ykuK]-[gene|899FF5BEE5D3F01778A0175E293EDBBDEB25717D|abbA]-[gene|90AFF93D6E7BC993B2773C12EE400C80A87A4831|darB]-[gene|FE15A41A58A8177280817CA3825764C39185021A|ccpC]
    description
    [Pubmed|16395550]

    regulatory mechanism

  • [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]: activation, by [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A]~P [Pubmed|18840696,14651647], in [regulon|2C54FE2ADC82FF414D732018C90649D477A925AD|Spo0A regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|16395550,12850135], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]
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    Biological materials

    Mutant

  • GP214 (deletion of ''[gene|A26502ADAC214D45A8F7F394587B0BDFBE7AF28E|ykuJ]-[gene|7FD784C885605F7FD27898BC9E83C28F21BE0E9D|ykuK]-[gene|899FF5BEE5D3F01778A0175E293EDBBDEB25717D|abbA]-[gene|90AFF93D6E7BC993B2773C12EE400C80A87A4831|darB]'', replaced by ''aphA3''), available in [SW|Jörg Stülke]'s lab
  • BKE14120 ([gene|899FF5BEE5D3F01778A0175E293EDBBDEB25717D|abbA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCAGGCCCCCTGTTTTA, downstream forward: _UP4_TAATGGGACACCCTATAATT
  • BKK14120 ([gene|899FF5BEE5D3F01778A0175E293EDBBDEB25717D|abbA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCAGGCCCCCTGTTTTA, downstream forward: _UP4_TAATGGGACACCCTATAATT

    • lacZ fusion

  • pGP708 (in [SW|pAC5]), available in [SW|Jörg Stülke]'s lab
  • pGP712 (in [SW|pAC6]), available in [SW|Jörg Stülke]'s lab

    • labs

  • [SW|Richard Losick], Harvard Univ., Cambridge, USA [http://www.mcb.harvard.edu/Losick/ homepage]

    • References

  • 24534728,18840696,14651647,12850135,16395550