SubtiBank SubtiBank
comS
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

comS

antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway
locus
BSU_03500
pI
9.15
mw
5.11 kDa
protein length
46 aa Sequence Blast
gene length
141 bp Sequence Blast
function
control of ComK degradation
product
antiadaptor protein (anti-MecA)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

    • Gene

    Coordinates
    390,880 391,020

    Phenotypes of a mutant

  • loss of [SW|genetic competence] [Pubmed|7752896]
  • overexpression of [protein|4D76F07D6124D56C7CEBBDAB9E84B2718BF1E7FC|ComS] results in expression of competence genes in 80% to 90% of the cells [Pubmed|8878039]

    • Expression and Regulation

    Operons

    genes
    [gene|81845F44CE2C601555066E31E87384FF5D7B4139|srfAA]-[gene|3C484FDB3A440269E87D6B6E8500A875AC456666|srfAB]-[gene|4D76F07D6124D56C7CEBBDAB9E84B2718BF1E7FC|comS]-[gene|1D5F227860A321506A1AB4BAE63CAD3A66E43BFC|srfAC]-[gene|9D0914FC38FFF4028C2BA5970DC87B3A1027E253|srfAD]
    description
    [Pubmed|1715856]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1715856], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]: activation, [Pubmed|25666134], in [regulon|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP regulon]
  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|8830686], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, [Pubmed|1715856,16091051], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]
  • [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR]: activation, [Pubmed|16166527], in [regulon|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR regulon]
  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: repression, [Pubmed|12642660], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]
  • [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh]: repression, [Pubmed|20817675], in [regulon|5872812AB61E92E2944E926915EB7FEE71BFA6D5|Abh regulon]

    • regulation

  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]

    • additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|hxlR]' and '[protein|search|srfAA]' [PubMed|20525796]
    • view in new tab

    Biological materials

    Mutant

  • BKE03500 ([gene|4D76F07D6124D56C7CEBBDAB9E84B2718BF1E7FC|comS]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE03500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG
  • BKK03500 ([gene|4D76F07D6124D56C7CEBBDAB9E84B2718BF1E7FC|comS]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK03500 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTGCCTGATCGGTTCAAACG, downstream forward: _UP4_AAGTAGATAAAGACCGGCTTG

    • References

    Reviews

  • 19609260

    • Original Publications

  • 17560370,10447896,12642660,9000055,10361283,10447896,11703662,1715856,16091051,20817675,8878039,7752896,27045827