SubtiBank SubtiBank
Category: Essential genes
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Category: Essential genes

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6. Groups of genes

6.1. Essential genes

NameFunction
accAproduction of malonyl-CoA, the substrate for fatty acid biosynthesis
accBproduction of malonyl-CoA, the substrate for fatty acid biosynthesis
accCproduction of malonyl-CoA, the substrate for fatty acid biosynthesis
accDproduction of malonyl-CoA, the substrate for fatty acid biosynthesis
acpAfatty acid biosynthesis
acpSfatty acid biosynthesis
adkADP formation
alaStranslation
alrpeptidoglycan biosynthesis
argStranslation
asdbiosynthesis of threonine, lysine, dipicolic acid, peptidoglycan
aspStranslation
birAregulation of biotin synthesis, addition of biotin to proteins
ccatRNA modification
cdsAbiosynthesis of phospholipids
cmksynthesis of CTP and dCTP
cspRtranslation
cysStranslation
dapAbiosynthesis of lysine and peptidoglycan
dapBbiosynthesis of lysine and peptidoglycan
dapFbiosynthesis of lysine and peptidoglycan
ddlpeptidoglycan precursor biosynthesis
dfrAbiosynthesis of folate
dgkBbiosynthesis of lipoteichoic acid
divIBseptum formation
divICseptum formation
dnaA[category|SW 3.1.1|DNA replication]
dnaB[category|SW 3.1.1|DNA replication]
dnaC[category|SW 3.1.1|DNA replication]
dnaD[category|SW 3.1.1|DNA replication]
dnaE[category|SW 3.1.1|DNA replication](lagging strand)
dnaG[category|SW 3.1.1|DNA replication]
dnaI[category|SW 3.1.1|DNA replication]
dnaN[category|SW 3.1.1|DNA replication], DNA repair
dnaX[category|SW 3.1.1|DNA replication]
dxsbiosynthesis of thiamine, MEP pathway of isoprenoid biosynthesis
enoenzyme in glycolysis/ gluconeogenesis
eraribosome assembly
fabDfatty acid biosynthesis
fabFfatty acid biosynthesis
fabGfatty acid biosynthesis
ffhpresecretory protein translocation
fmtformylation of Met-tRNA(fMet)
folDformylation of Met-tRNA(fMet)
frrtranslation
ftsLseptum formation
ftsWcell division
ftsZformation of Z-ring
fusAtranslation
gapAcatabolic enzyme in glycolysis
gatAtranslation
gatBtranslation
gatCtranslation
gcaDcell wall metabolism
glmMcell wall synthesis
glmScell wall synthesis
gltXtranslation
glyAbiosynthesis of glycine
glyQtranslation
glyStranslation
gmkGTP biosynthesis
gpsAbiosynthesis of phospholipids
groELprotein folding and re-folding
groESprotein folding and re-folding
guaBbiosynthesis of GMP
gyrADNA supercoiling, control of [category|SW 3.1.1|replication] initiation
gyrBDNA supercoiling, control of [category|SW 3.1.1|replication] initiation
hbsDNA packaging, function of the signal recognition complex
hepSmenaquinone biosynthesis
hepTmenaquinone biosynthesis
hisStranslation
hlpBrescuing of AddA-AddB-mediated recombination intermediates
holA[category|SW 3.1.1|DNA replication]
holB[category|SW 3.1.1|DNA replication]
hprTpurine salvage and interconversion, control of ftsH expression
ileStranslation
infAtranslation
infBtranslation
infCtranslation
ispCMEP pathway of isoprenoid biosynthesis
ispDMEP pathway of isoprenoid biosynthesis
ispEMEP pathway of isoprenoid biosynthesis
ispFMEP pathway of isoprenoid biosynthesis
ispGMEP pathway of isoprenoid biosynthesis
ispHMEP pathway of isoprenoid biosynthesis
leuStranslation
ligAreplication
lipAsynthesis of lipoic acid
lysStranslation
mapremoval of N-terminal methionine from nascent proteins
menAbiosynthesis of menaquinone
menBbiosynthesis of menaquinone
menCbiosynthesis of menaquinone
menDbiosynthesis of menaquinone
menEbiosynthesis of menaquinone
metKS-adenosylmethionine synthesis
metStranslation
mnaAbiosynthesis of teichoic acid
mraYpeptidoglycan precursor biosynthesis
mreB[SW|cell shape] determination
mreCcell shape determation
mreDcell shape determation
mrpAsodium export
mrpBsodium export
mrpCsodium export
mrpDsodium export
mrpEsodium export
mrpFsodium export
mrpGsodium export
murAApeptidoglycan precursor biosynthesis
murBpeptidoglycan precursor biosynthesis
murCpeptidoglycan precursor biosynthesis
murDpeptidoglycan precursor biosynthesis
murEpeptidoglycan precursor biosynthesis
murFpeptidoglycan precursor biosynthesis
murGpeptidoglycan precursor biosynthesis
nadDNAD biosynthesis
nadENAD biosynthesis
nadFgeneration of NADP from NAD
nrdEsynthesis of deoxyribonucleoside triphosphates
nrdFsynthesis of deoxyribonucleoside triphosphates
nrdIsynthesis of deoxyribonucleoside triphosphates
nusAtranscription
obgribosome assembly, may be required to stimulate activity
parCchromosome segregation and compaction
parEchromosome segregation and compaction
patAbiosynthesis of lysine and peptidoglycan
pbpBseptation, [SW|cell division]
pcrAplasmid rolling-circle replication, conjugative transfer of ICEBs1
pdhAlinks glycolysis and TCA cycle
pgmenzyme in glycolysis / gluconeogenesis
pgsAbiosynthesis of phospholipids
pheStranslation
pheTtranslation
plsCbiosynthesis of phospholipids
plsXbiosynthesis of phospholipids
plsYbiosynthesis of phospholipids
pncBunknown
polC[category|SW 3.1.1|DNA replication]
ppaCrecovery of phosphate ions from pyrophosphate
prfAtranslation
prfBtranslation
priA[category|SW 3.1.1|DNA replication]initiation
proStranslation
prsphosphoribosylpyrophosphate synthesis (biosynthesis of histidine)
prsAprotein folding
pyrGpyrimidine biosynthesis
racEpeptidoglycan precursor biosynthesis
rbgAribosome assembly
resBcytochrome c biogenesis
resCcytochrome c biogenesis
ribCFAD biosynthesis
rncprocessing and degradation of RNA molecules
rnjARNA processing
rnpAcleavage of precursor sequences from the 5 ends of pre-tRNAs
rnpBcleavage of precursor sequences from the 5 ends of pre-tRNAs
rnzprocessing of CCA-less tRNA precursors
rodAcontrol of cell shape and elongation
rplBtranslation
rplCtranslation
rplDtranslation
rplEtranslation
rplFtranslation
rplJtranslation
rplLtranslation
rplMtranslation
rplNtranslation
rplPtranslation
rplQtranslation
rplRtranslation
rplStranslation
rplTtranslation
rplUtranslation
rplXtranslation
rpmAtranslation
rpmDtranslation
rpoAtranscription
rpoB[SW|transcription]
rpoC[SW|transcription]
rpsBtranslation
rpsCtranslation
rpsDtranslation
rpsEtranslation
rpsGtranslation
rpsHtranslation
rpsItranslation
rpsJtranslation
rpsKtranslation
rpsLtranslation
rpsMtranslation
rpsNtranslation
rpsOtranslation
rpsPtranslation
rpsQtranslation
rpsRtranslation
rpsStranslation
scpAsegregation of replication origins
scpBsegregation of replication origins
scrpresecretory protein translocation
secAprotein secretion
secEprotein secretion
secYprotein secretion
serStranslation
sigAtranscription
sknRcontrol of prophage gene expression
smcsegregation of replication origins
spoVCspore coat formation
ssbA[category|SW 3.1.1|DNA replication], [category|SW 3.1.5|DNA repair/ recombination]
sufBsynthesis of iron-sulfur clusters
sufCsynthesis of Fe-S clusters
sufDsynthesis of Fe-S-clusters
sufSformation of iron-sulfur clusters in proteins
sufUtransfer of sulfur from [protein|search|SufS ]to [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|SufB]
sunIimmunity to sublancin
tagAbiosynthesis of teichoic acid
tagBbiosynthesis of teichoic acid
tagDbiosynthesis of teichoic acid
tagFbiosynthesis of teichoic acid
tagG[category|SW 2.6.1.3|Biosynthesis of teichoic acid]
tagH[category|SW 2.6.1.3|Biosynthesis of teichoic acid]
tagObiosynthesis of teichoic acid
tilStRNA modification, control of ftsH expression
tmkTTP biosynthesis
topArelaxation of negatively supercoiled DNA behind RNA polymerase
trmDtRNA modification
trmUtRNA modification
trpStranslation
trxAprotection of proteins against oxidative damage
trxBkeeps TrxA|thioredoxin in the reduced state
tsaBtRNA modification
tsaDtRNA modification
tsftranslation
tufAtranslation
tyrStranslation
uppScell wall biosynthesis
valStranslation
walKcontrol of cell wall metabolism
walRcontrol of cell wall metabolism
ydiOBsuM DNA modification
ydiPBsuM DNA modification
yhdLcontrol of [protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|SigM] activity
ykuQbiosynthesis of lysine and peptidoglycan
ykuRbiosynthesis of lysine and peptidoglycan
ylaNunknown
yphCribosome assembly
yqeGunknown
yqeHribosome assembly
yqfG16S rRNA maturation
yrvOtRNA modification
ysgAunknown
ysxCribosome assembly
ytaGsynthesis of coenzyme A
ytbEunknown
yumCredox reactions that involve ferredoxin and flavodoxin
ywpBfatty acid biosynthesis
yxlCcontrol of SigY activity

important original publications

  • 12682299,17114254,17005971,23420519,24178028,25092907