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Category: Transcription factors and their control
Save the date! 20th International Conference on Bacilli and Gram-Positive Bacteria. Washington, D.C. July 23-26, 2019.

Category: Transcription factors and their control

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3. Information processing

3.4. Regulation of gene expression

3.4.2. Transcription factors and their control

3.4.2.1. Two-component system response regulators

NameFunction
bceRresistance against toxic peptides
cheYmodulation of flagellar switch bias
citTregulation of citrate uptake
comAregulation of genetic competence and quorum sensing
cssRcontrol of cellular responses to protein secretion stress
dctRregulation of the [gene|9A96572B101358768EB20EE9438BE0E1424A4130|dctS]-[gene|97C34F6FA0B89D93369150E9A8AB3579332B07BC|dctR]-[gene|search|dctP ]operon
degUregulation of degradative enzymes, [SW|genetic competence], and other adaptive responses
desRregulation of cold shock expression of [gene|644C0C354B72FC07222EE45F4D2E0E57434B5EB5|des]
glnLregulation of the glsA-glnT operon
liaRregulation of the [gene|B6D1159454969D1D578E05D5CE2259E079688510|liaI]-[gene|AE4BF12C368468C553EED7A696D5EFC63F56CA39|liaH]-[gene|A71B0392FFF70EFFC096E7E9BD5FE30792821CDD|liaG]-[gene|C107A958DFA2B0DA4837E2F9F648CD329A3116AC|liaF]-[gene|9A1871BD853254EEA8B4E78CA187F9315CBDF43D|liaS]-[gene|search|liaR ]operon
lnrKresistance to linearmycin
lytTcontrol of pyruvate utilization
malRregulation of malate uptake
natRregulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|search|natB ]operon
phoPregulation of phosphate metabolism ([gene|E0430C16C41440633647976A0F9183E24268E198|phoA], [gene|3B95AB3021280215B6B487A348D78FB5797AEEA6|phoB], [gene|597771E2E8EC31ED9B2CC8C0E4D888DEEA80F689|phoD], [gene|F7D869F77E2275110737EF658C58FA1BF742D73F|resABCDE], [gene|72A89412C53703F96F835D26307263F5D1A4AB4E|tagA]-[gene|911A4D957A6C0DFC636A152395119DBFC777DDA2|tagB], [gene|8620DA76A1953D7ACDFA7E46ED81EF1A0D97999C|tagDEF], [[gene|tuaA|tuaA-H]])
psdRresistance against toxic peptides
resDregulation of aerobic and anaerobic respiration
spo0Ainitiation of [SW|sporulation]
walRcontrol of cell wall metabolism
ybdJunknown
ycbLunknown
yclJunknown
ydfIcontrol of [gene|search|ydfJ ]expression
yesNunknown
yhcZunknown
ykoGunknown
yneIunknown
yrkPunknown
yvfUunknown
yvrHbregulation cell surface maintenance
yxdJresistance against toxic peptides
yxjLunknown

Key publications

  • 30008469,31100988
  • 3.4.2.2. Control of two-component response regulators

    Key publications

  • 30008469
  • 3.4.2.3. PRD-type regulators

    NameFunction
    glcTcontrol of glucose uptake
    levRregulation of levan and fructose utilization
    licRregulation of lichenan utilization
    licTcontrol of beta-glucan and beta-glucoside utilization
    manRregulation of mannose utilization
    mtlRregulation of mannitol utilization
    sacTregulation of sucrose utilization
    sacYregulation of sucrose utilization

    Key publications

  • 9663674,31100987
  • 3.4.2.4. Control of PRD-type regulators

    NameFunction
    bglPbeta-glucoside uptake and phosphorylation, control of [protein|search|LicT ]activity
    levEfructose uptake and phosphorylation, control of [protein|1D2043CC0D8CF64142F0A5993A936C5A196726D4|LevR] activity
    licBlichenan uptake and phosphorylation, control of LicR activity
    manPmannose uptake and phosphorylation, control of [protein|F273002AF97D87BB025B4F014C328C5592EAD621|ManR] activity
    mtlAmannitol uptake and phosphorylation, control of [protein|1CEDC98C9EDD8F3DEA0AF4B2104DA1BF86E688C2|MtlR] activity
    ptsGglucose transport and phosphorylation, control of [protein|BC0DF593AE969F1DBC5E9E2BACF1C00BE4FEE449|GlcT] activity
    sacPsucrose uptake and phosphorylation, control of [protein|6796E1C147AA21E919A42A953884DC24E182F430|SacT] activity
    sacXsucrose uptake and phosphorylation, control of [protein|EB330AB3DC6C8C3EC72C4CAFA2BC59CC485EE344|SacY] activity

    3.4.2.5. Transcription factors/ other

    NameFunction
    acoRregulation of acetoin utilization
    adaAadaptive response to alkylative DNA damage
    adeRcontrol of [gene|2D346CF412BA32EE18111DA930CFA1306F95024B|ald] expression
    adhRregulation of the protective response to formaldehyde and methylglyoxal
    ahrCtranscriptional regulator of arginine metabolic genes
    alaRunknown
    alsRregulation of acetoin synthesis ([gene|AAA45830B9C5428CADFA5551D33B513E9B1B7C8E|alsS]-[gene|355E70F55A28C6C2C24E8E326EFB673AC303FBEE|alsD])
    ansRnegative regulation of the [gene|FED8E46AA1C4EFD27796D5DFBBB1663EBF336BFD|ansA]-[gene|search|ansB ]operon
    araRregulation of arabinose utilization
    arfMregulation of anaerobic genes
    arsRregulation of As (III) efflux
    ascRregulation of sulphur metabolism
    aseRregulation of As (III) efflux
    azlBregulation of branched-chain amino acid transport
    birAregulation of biotin synthesis, addition of biotin to proteins
    bkdRregulation of branched-chain amino acid utilization
    bltRregulation of spermidine efflux and degradation
    bmrRregulation of multidrug resistance
    bsdAregulation of resistance to salicylic acid
    btrregulation of iron acquisition
    catRresistance against oxidative and electrophile stress
    ccpAcarbon catabolite repression (CCR)
    ccpBunknown
    ccpCregulation of tricarboxylic acid branch of the TCA cycle
    ccpNrepressor of genes involved in gluconeogenesis ([gene|C1B89BD3DD27CD566018558D3A7845FB451056F0|gapB], [gene|74D4616D1A550D87182FAAC2A4AF6E04F81E1572|pckA]) and of [gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]
    cggRtranscriptional regulator
    chrSregulation of chromate export
    citRregulation of the minor citrate synthase
    codYregulation of a large regulon in response to branched-chain amino acid limitation
    comKregulation of [SW|genetic competence] and DNA uptake
    csoRcontrol of copper homeostasis
    ctsRregulation of protein degradation
    cymRregulation of sulfur metabolism
    cysLregulation of cysteine biosynthesis
    czrAregulation of resistance against toxic metal cations
    deoRregulation of deoxyribonucleotide utilization
    dtrRresistance to D-Tyr
    exuRregulation of hexuronate utilization
    fadRregulation of fatty acid degradation
    fapRregulation of fatty acid biosynthesis
    fatRunknown
    fnrregulation of anaerobiosis, fermentation and overflow metabolism
    frlRregulation of utilization of sugar amines
    fruRregulation of fructose utilization
    furregulation of iron homoeostasis
    gabRregulation of gamma-amino butyric acid utilization
    gamRregulation of glucosamine utilization
    ganRregulation of galactan utilization
    gbsRregulation of osmoprotection
    gerEregulation of [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]-dependent gene expression
    gerRspore coat formation and resistance of spores to lysozyme
    glcRunknown
    glnRregulation of glutamine synthesis
    glpPregulation of glycerol and glycerol-3-phosphate utilization
    gltCpositive regulation of the glutamate synthase operon ([gene|44DF1B7E476AD58B3CCC39300FFE0132D0D32AD0|gltA]-[gene|AA07CC52B2DD48ACC9D3375E9D531CB1ACBE485A|gltB])
    gltRunknown
    glvRregulation of maltose utilization
    gmuRregulation of glucomannan utilization
    gntRregulation of gluconate utilization
    gutRregulation of glucitol utilization
    hprTpurine salvage and interconversion, control of [gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] expression
    hrcAregulation of chaperone gene expression
    hutPregulation of histidine utilization
    hxlRregulation of the ribulose monophosphate pathway
    hypRcontrol of the nitroreductase gene [gene|9DF5999568760E016ECA988385A1FA61A257D486|hypO] in response to disulfide stress (diamide, NaOCl)
    immRcontrol of transfer of the mobile genetic element ICEBs1
    iolQcontrol of scyllo-inositol utilization
    iolRregulation of myo-inositol catabolism
    kdgRregulation of galacturonic acid utilization
    kipRregulation of [SW|sporulation] initiation
    lexAregulation of DNA damage repair
    lmrAregulation of lincomycin resistance
    lrpArepression of [gene|BAE8062DA8538C9C83FFBA9684BECE9613EEFD2F|glyA] transcription and [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|KinB]-dependent [SW|sporulation]
    lrpBrepression of [gene|BAE8062DA8538C9C83FFBA9684BECE9613EEFD2F|glyA] transcription and [protein|2111AC1AE49D1006E10DC127BF5B7A0327DE94A7|KinB]-dependent [SW|sporulation]
    lutRcontrol of lactate utilization
    mdtRregulation of the multidrug-resistance [gene|795D70E8A4D750140D6B1AA4BFEBD25C2A389C85|mdtR]-[gene|search|mdtP ]operon
    melRregulation of melibiose utilization
    mgsRcontrols a subset of general stress genes
    mhqRregulation of resistance to quinones and diamide
    mntRregulation of manganese transport
    mtaregulation of multidrug-efflux transporter genes
    mtrBregulation of tryptophan biosynthesis(and translation) attenuation in the trp operon;repression of the folate operon
    murRregulation of muramic acid utilization
    nadRregulation of NAD biosynthesis
    nagRregulator of the [gene|8F4D075C9B9EF995E361F9BA5E8B52F42059C422|nagA]-[gene|0C8D7EAC2656E989E45B5B7E42FAA6D258956B56|nagB]-[gene|6D36D6360FE1CBFF5F64B2A6D1406405D6C6F7D5|nagR] operon
    nrdRcontrol of ribonucleotide reductase expression
    nsrRrepression of [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]-[protein|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|ResE]-dependent genes in the absence of nitric oxide (NO)
    ntdRregulation of the [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|search|glcP ]operon
    ohrRregulation of [gene|869E46AECF6249610F8541E403D834284B62171D|ohrA] expression in response to organic peroxides
    opcRregulation of choline uptake
    padRregulation of the phenolic acid stress response
    paiBregulation of sporulation, degradative enzyme and motility genes
    pamRcontrol of the [gene|20D50DA11B864E6C719CC34BE27C7900893EA054|ydcF]-[gene|89AB146F447696EF1CBE219C9A2FB5CBB380F847|ydcG]-[gene|search|pamR ]operon
    perRregulation of the response to peroxide
    pksAunknown
    pucRregulation of purine utilization
    purRregulation of purine biosynthesis
    putRregulation of proline utilization
    pyrRregulation of pyrimidine biosynthesis
    qdoRcontrol of quercetin utilization
    rbsRregulation of ribose utilization
    remAcontrol of biofilm formation
    rexregulation of fermentation and anaerobic respiration
    rghRregulation of [SW|sporulation ]initiation
    rhaRcontrol of rhamnose utilization
    rhgRregulation of pectin utilization
    rocRtranscriptional activator of arginine utilization operons
    rokregulation of genetic competence
    scoCtransition state regulator
    sdpRregulation of protection against [protein|820635420B3980B620F3E3D7ACF7EDE9DC6275AD|SdpC]
    senSregulation of extracellular enzyme genes
    sinRcontrol of [SW|biofilm formation]
    sknRcontrol of prophage gene expression
    slrRregulation of initiation of [SW|biofilm formation] and of autolysis
    splAregulation of the splA-splB operon
    spoIIIDregulation of mother cell gene expression
    spoVTregulation of forespore gene expression
    spxnegative and positive regulator of many genes
    thrRcontrol of threonine biosynthesis
    tilStRNA modification, control of [gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] expression
    tnrAregulation of nitrogen assimilation
    treRregulation of trehalose utilization
    xreregulation of PBSX prophage gene expression
    xylRregulation of xylan and xylose utilization
    ycbGregulation of glucarate/galactarate utilization
    ycnKregulation of copper uptake
    yetLregulation of [gene|A70EA4AEBF46ED2279E8BCE8A28439078484B6E3|yetM] expression
    yfmPregulation of the [gene|36AF02B4EB416ABCA3F0E4C5A4126E777A20C7D1|yfmP]-[gene|D91356CF66ADE0CFA9E95A686DC7355B348C8B5C|yfmO] operon
    yhdQunknown
    ykrKregulation of membrane protein quality control
    yodBregulation of quinone and diamide detoxification
    yofAcontrol of [gene|8AB7D225DBEE6BD695A4A8A2384D2C029B571C57|ftsW] expression
    yplPrequired for survival at low temperatures
    ytrAcontrol of cell envelope stress responses
    ywcCcontrol of [gene|C17C296F3EB2E106C380E3B5D784F3FA63F4C9B7|slrA] expression
    zurregulation of zinc homeostasis([gene|75DB07A2704FEC2932BD0CDD24E2B3454E9551E1|zagA], [gene|D33A144568CAF32FFE4A2A46BE67573DB66FC1A1|znuA]-[gene|6B5D4FD32CCE72C99B915B0F1EB4B8E8D42A04B3|znuC]-[gene|EE212953BC83BD6D69BF769D6E917F4F954BE1E2|znuB])

    3.4.2.6. Transcription factor/ other/ based on similarity

    NameFunction
    rmgRunknown
    whiAcontrol of Z ring asembly and chromosome segregation
    yazBunknown
    ybfIunknown
    ybfPunknown
    ybzHunknown
    yceKunknown
    ycgEunknown
    ycgKunknown
    ycnCunknown
    ycxDunknown
    yczGunknown
    ydeBunknown
    ydeCunknown
    ydeEunknown
    ydeFunknown
    ydeLunknown
    ydePunknown
    ydeSunknown
    ydfDunknown
    ydfFunknown
    ydfLunknown
    ydgCunknown
    ydgGunknown
    ydgJunknown
    ydhCunknown
    yerCunknown
    yerOunknown
    yezCunknown
    yezEunknown
    yfiFunknown
    yfiRcontrol of [gene|search|yfiS ]expression
    yfiVunknown
    ygzDunknown
    yhbIunknown
    yhcFunknown
    yhdIunknown
    yhgDunknown
    yhjHunknown
    yisRunknown
    yisVunknown
    yizBunknown
    ykoMunknown
    ykvNunknown
    ykvZunknown
    ymfCunknown
    yoaUunknown
    yobDunknown
    yobQunknown
    yobSunknown
    yonRunknown
    yopOunknown
    yopSunknown
    yotLunknown
    yozGunknown
    ypoPunknown
    yqaFunknown
    yqaGunknown
    yraNunknown
    yrdQunknown
    ysfBunknown
    ysmBunknown
    ytcDunknown
    ytoIunknown
    ytzEunknown
    yusTunknown
    yuzNunknown
    yvaFunknown
    yvaOunknown
    yvaVunknown
    yvbUunknown
    yvdEprobably regulation of starch and maltodextrin utilization
    yvdTunknown
    yvkBunknown
    yvzCunknown
    ywbIcontrol of expression of the [gene|7DA08C189F5524D4874E2F4828264AB2671A5460|ywbH]-[gene|2940E73F0BCAB69992BBD224402C95C2667757AD|ywbG] operon
    ywhAunknown
    ywoHunknown
    ywqMunknown
    ywzGunknown
    yxaDunknown
    yxbFunknown
    yxjOunknown
    yyaNunknown
    yybAunknown
    yybEunknown
    yydKunknown

    3.4.2.7. Control of transcription factor (other than two-component system)

    NameFunction
    abbAinhibition of [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|AbrB]
    crhcontrol of carbon flux
    cysKbiosynthesis of cysteine, control of [protein|50930C56C27D22715620A350220E3C56ADB41020|CymR] activity
    glnAglutamine biosynthesis, control of [protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|TnrA] and [protein|641C4BDD9702804642E1753A9C779E80FABB3919|GlnR] activity
    gudBglutamate utilization, control of [protein|87BCAE725B02860156D50E1783F6DB68510C811E|GltC] activity
    hprKcarbon catabolite repression,phosphorylation of [protein|29B793660E4D30C0656248F3EF403FEF76FB9025|HPr] and [protein|A269774F2FDC94F93BA5F1360FFFE754B50383AD|Crh] proteins at Ser46
    hprTpurine salvage and interconversion, control of [gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] expression
    immAcontrol of [protein|DD1C8F3A4809785BD6A6047D39B42AB2C605E161|ImmR] activity
    mcsAcontrol of [protein|908DB17A39D518E84977250C55825E77FA02E391|CtsR] activity
    mcsBcontrol of [protein|908DB17A39D518E84977250C55825E77FA02E391|CtsR] activity
    nrgBregulation of ammonium uptake
    phrIcontrol of the transfer of the mobile genetic element ICEBs1
    ptsHPTS-dependent sugar transport and carbon catabolite repression
    rapIcontrol of transfer of the mobile genetic element ICEBs1
    rocGarginine utilization, controls the activity of [protein|87BCAE725B02860156D50E1783F6DB68510C811E|GltC]
    rtpAregulation of tryptophan biosynthesis
    salAcontrol of alkaline protease expression
    sinIcontrol of [SW|biofilm formation]
    slrAcontrol of motility and biofilm formation
    tilStRNA modification, control of [gene|4E7B9426CED372AA8A321A147116A3A589FBF20C|ftsH] expression
    ylbFcontrol of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [SW|Targets of the Y complex]
    ymcAcontrol of [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] activity, see [SW|Targets of the Y complex]
    yqfLinhibits [protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN] activity

    reviews on transcription regulation

  • 19721087,19632156,16772031,18599813,22210308,23504016,22728391