SubtiBank SubtiBank
Category: Carbon core metabolism
An ordered knock out library of all non-essential genes in B. subtilis is now available at Addgene. Information on ordering a copy can be found here. See Koo et al. 2017 for details about library construction.

Category: Carbon core metabolism

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2. Metabolism

2.2. Carbon metabolism

2.2.1. Carbon core metabolism

2.2.1.1. Glycolysis

NameFunction
cggRtranscriptional regulator
enoenzyme in glycolysis/ gluconeogenesis
fbaAenzyme in glycolysis/ gluconeogenesis
gapAcatabolic enzyme in glycolysis
glcTcontrol of glucose uptake
mgsAbypass of glycolysis
pfkAcatabolic enzyme in glycolysis
pgienzyme in glycolysis / gluconeogenesis
pgkenzyme in glycolysis/ gluconeogenesis
pgmenzyme in glycolysis / gluconeogenesis
ptsGglucose transport and phosphorylation, control of GlcT activity
pykcatabolic enzyme in glycolysis
tpienzyme in glycolysis/ gluconeogenesis

2.2.1.2. Gluconeogenesis

NameFunction
ccpNrepressor of genes involved in gluconeogenesis ([gene|C1B89BD3DD27CD566018558D3A7845FB451056F0|gapB], [gene|74D4616D1A550D87182FAAC2A4AF6E04F81E1572|pckA]) and of [gene|FC93BA60BD185DE5EF31D5605F0B8294EC2E8E5A|sr1]
enoenzyme in glycolysis/ gluconeogenesis
fbaAenzyme in glycolysis/ gluconeogenesis
fbpgluconeogenesis
gapBanabolic enzyme in gluconeogenesis
glpXgluconeogenesis
pckAsynthesis of phosphoenolpyruvate
pgienzyme in glycolysis / gluconeogenesis
pgkenzyme in glycolysis/ gluconeogenesis
pgmenzyme in glycolysis / gluconeogenesis
tpienzyme in glycolysis/ gluconeogenesis
yqfLinhibits [protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|CcpN] activity
yvcKlocalization of [protein|A8EEC896B279CFDDE9C3A6F146A04EC822E33A4F|PBP1]

2.2.1.3. Pentose phosphate pathway

NameFunction
gndApentose phosphate pathway
rpepentose phosphate pathway
tktpentose phosphate pathway
ykgBpentose phosphate pathway
ywjHpentose phosphate pathway
ywlFpentose phosphate pathway
zwfinitiation of the pentose phosphate pathway

2.2.1.4. TCA cycle

NameFunction
ccpCregulation of tricarboxylic acid branch of the TCA cycle
citBTCA cycle
citGTCA cycle
citZTCA cycle
icdTCA cycle
mdhTCA cycle
odhATCA cycle
odhBTCA cycle
pdhAlinks glycolysis and TCA cycle
pdhBlinks glycolysis and TCA cycle
pdhClinks glycolysis and TCA cycle
pdhDlinks glycolysis and TCA cycle, enzyme in TCA cycle
pycAreplenishment of the oxaloacetate pool
sdhATCA cycle
sdhBTCA cycle
sdhCTCA cycle
sucCTCA cycle
sucDTCA cycle

2.2.1.5. Overflow metabolism

NameFunction
ackAoverflow metabolism
alsDoverflow metabolism
alsRregulation of acetoin synthesis (alsS-alsD)
alsSoverflow metabolism
bdhAoverflow metabolism, fermentation
lctPlactate excretion
ldhoverflow metabolism, fermentation
ptaoverflow metabolism
rexregulation of fermentation and anaerobic respiration

important original publications

  • 20933603, 19193632 ,12850135,11489127,19917605,18586936,9131624 ,18302748,24727859
  • reviews

  • 11018147,19202299,17982469,16102602,22545791