walH

walH
168

negative effector of [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|walK], controls cell wall metabolism

locus
BSU_40390
Molecular weight
52.05 kDa
pI
5.59
Protein length
Gene length
function
control of cell wall metabolism
product
negative effector of [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|walK]
essential
no
synonyms
walH, yycH

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4863 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,150,496  4,151,863
Phenotypes of a mutant
growth defect at high temperature, lysis at 49C, this can be suppressed by mutations that reduce [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|walK] autokinase activity, by inactivation of [gene|321F248C22D7283C0F3323F1F4069E36F8D7FE6C|lytE], or by overexpreesion of [protein|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA] or [protein|603E226CE488A25C4E28A6A7363CCD65BE64BB21|pdaC] [pubmed|29465029]
defective in [category|SW.4.1.4|Swarming] motility (periodic cessation and reinitiation of [category|SW.4.1.4|Swarming] motility, terracing colonies) [pubmed|35638827]
additional information
the gene readily acquires mutations during cultivation with Arabidopsis thaliana roots [pubmed|37768063]
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The protein
Structure
[PDB|2FGT]
[AF|Q794W0]
[wiki|Localization]
cell membrane (according to UniProt), spotty close to the membrane [Pubmed|21219466]
Expression and Regulation
Operons
genes
[gene|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]-[gene|E88978809272FAC2520DB4ABCA0554F8028F3451|walK]-[gene|06D2D03C65D50E3909B2C93835193815B6016967|walH]-[gene|EE681C9A42FCC29CBB55CC9566EE4CFF986D0F1D|walI]-[gene|D5321F707E183E72B225F1CED2F2FDCB1183B88A|walJ]-[gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]
description
[Pubmed|9829949]
regulation
''htrC'' transcript expressed during sporulation [Pubmed|9829949]
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[gene|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]→[gene|75B8C37E589C855D2BAD7FB51B9600E161ACFBD3|htrC]

2024-03-24 13:36:40

ghost

104

4e891bb3dceb8eda2e5ad4f9ed646a611afbe349

32BB8D419E54714C8925B07FBBCF691251CA4145

Biological materials
Mutant
MGNA-B826 (yycH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1825 NBRP B. subtilis, Japan]
BKE40390 ([gene|06D2D03C65D50E3909B2C93835193815B6016967|walH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40390 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTAAGTAATATCGTTTTTA,  downstream forward: _UP4_TTATTGAGGAAGGAGGGGGC
BKK40390 ([gene|06D2D03C65D50E3909B2C93835193815B6016967|walH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40390 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CGTAAGTAATATCGTTTTTA,  downstream forward: _UP4_TTATTGAGGAAGGAGGGGGC
References
Reviews
28886686
Original Publications
17307850,17350627,16600972,9829949,16030236,18408157,21219466,29465029,35638827,37768063

06D2D03C65D50E3909B2C93835193815B6016967

Page visits: 2720

Time of last update: 2024-03-28 09:08:57

Author of last update: Jstuelk