phoC
168
[wiki|HAD superfamily] sugar phosphate phosphatase, dephosphorylation of N-acetyl-glucosamine 6-phosphate
locus
BSU_36290
Molecular weight
31.80 kDa
pI
4.88
function
detoxification of sugar phosphates
product
sugar phosphate phosphatase
essential
no
synonyms
phoC, ywpJ
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0561 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,738,343 → 3,739,200
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The protein
Catalyzed reaction/ biological activity
dephosphorylates glycerol 3-phosphate and ribose 5- phosphate [pubmed|30782637]
dephosphorylation of N-acetyl-glucosamine 6-phosphate [pubmed|32965679]
Protein family
[wiki|HAD superfamily] (according to UniProt)
[wiki|Cof family] (according to UniProt)
[wiki|Cofactors]
Mg2+ [pubmed|30782637]
Structure
[PDB|1NRW]
[AF|P94592]
Modification
phosphorylated on Arg-258 [Pubmed|22517742]
Expression and Regulation
Operons
genes
[gene|6F5831A480B72D17B7B3F0BF7AF147603B65CA49|glcR]-[gene|AF9523D3AA3C032B70175BCFFED34E9A42ED01AF|phoC]
description
[Pubmed|30782637,22383849]
regulation
induced by phosphosugar stress [Pubmed|30782637]
regulatory mechanism
[protein|6F5831A480B72D17B7B3F0BF7AF147603B65CA49|glcR]: repression, [pubmed|30782637], in [regulon|protein:6F5831A480B72D17B7B3F0BF7AF147603B65CA49|glcR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [pubmed|30782637], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A531 (ywpJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/531 NBRP B. subtilis, Japan]
BKE36290 (Δ[gene|AF9523D3AA3C032B70175BCFFED34E9A42ED01AF|phoC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATCGCAATTAATTTCACGT, downstream forward: _UP4_TAAGTATATGTGCTGCCACA
BKK36290 (Δ[gene|AF9523D3AA3C032B70175BCFFED34E9A42ED01AF|phoC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATCGCAATTAATTTCACGT, downstream forward: _UP4_TAAGTATATGTGCTGCCACA
References
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Time of last update: 2024-04-20 01:36:54
Author of last update: Jstuelk