sppI

sppI
168

antagonist of [protein|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA], stress protein

locus
BSU_29520
Molecular weight
18.98 kDa
pI
9
Protein length
Gene length
function
inhibition of [protein|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA] protease activtiy
product
[protein|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA] regulator protein
essential
no
ec
null
synonyms
sppI, yteJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1714 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,019,533  3,020,027
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The protein
Catalyzed reaction/ biological activity
binds to and thereby inhibits [protein|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA] [pubmed|33028682]
[wiki|Domains]
RDD domain (aa 26-158) (according to UniProt)
Structure
[AF|O34424]
[wiki|Localization]
cell membrane [pubmed|33028682]
Expression and Regulation
Operons
genes
[gene|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA]-[gene|618337D9BCD1586C5874746D1001DA3A2724E57C|sppI]
description
[Pubmed|9987136]
regulation
induced in response to cell wall stress ([protein|search|SigW]) [Pubmed|12207695]
sigma factors
[protein|3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW]: sigma factor, [Pubmed|9987136,12207695], in [regulon|protein:3D974DD2967C7F8FD4E3C2AF42617B8AE9F0296D|sigW regulon]
additional information
self-processes its own C-termini [PubMed|24228759]
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[gene|ACB7F015027A83C5D3457818A71B6F47192CEFBE|sppA]→[gene|618337D9BCD1586C5874746D1001DA3A2724E57C|sppI]

2024-03-28 13:45:45

ghost

74

fe4ea970b049e58e6ace5cd905f3c2fe02d6fbfa

713591724CAF4DF2F847A19D64AF155120CBB192

Biological materials
Mutant
MGNA-A110 (yteJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/110 NBRP B. subtilis, Japan]
BKE29520 ([gene|618337D9BCD1586C5874746D1001DA3A2724E57C|sppI]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29520 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTCGCGTCCATTATTGTTC,  downstream forward: _UP4_TAACCGATAACCCGGACTTC
BKK29520 ([gene|618337D9BCD1586C5874746D1001DA3A2724E57C|sppI]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29520 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGTCGCGTCCATTATTGTTC,  downstream forward: _UP4_TAACCGATAACCCGGACTTC
References
9987136,12207695,31424929,33028682

618337D9BCD1586C5874746D1001DA3A2724E57C

Page visits: 1467

Time of last update: 2024-03-22 19:51:45

Author of last update: Jstuelk