aimP
168
peptide, part of the arbitrium peptide-based communication system, Phage SP beta lysogeny promoter
locus
BSU_20850
Molecular weight
4.08 kDa
pI
6.26
function
control of phage SP beta lysogeny
product
arbitrium peptide
essential
no
ec
null
synonyms
aimP, AimP, yopL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
2,208,855 2,208,980
Phenotypes of a mutant
increased prophage production [pubmed|34562384]
sharper plaque morphology (similar to [gene|01BE35FB190DDC77BE19C013A8E0D980B132CBE1|yopN] mutant) [pubmed|34562384]
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The protein
Catalyzed reaction/ biological activity
Proteolytically cleaved in extracellular space to yield hexapeptide (GMPRGA) regulator. Hexapeptide re-enters cells and binds to [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR] to promote SPbeta lysogeny. ([Pubmed|31149347])
Structure
Hexapeptide bound to [protein|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]: [PDB|5Y24] ([Pubmed|30224798]), [PDB|5ZW6] ([Pubmed|30323253]), [PDB|6IM4] ([Pubmed|30421358]), [PDB|6HP5] ([Pubmed|30745087]), [PDB|6JG9] ([Pubmed|31149347])
[AF|O31926]
Expression and Regulation
Operons
genes
[gene|CAE7D8E45DA7CDE99D3EA114DF7E368A0A126389|aimR]-[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
expression
repressed by [protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]
regulatory mechanism
[protein|7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR]: repression, in [regulon|protein:7F82DED7C941BC501B6F810BF6541780AB87EDDD|mrpR regulon]
genes
[gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]
description
[pubmed|22383849]
regulation
expressed during the lytic cycle [pubmed|34562384]
regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: transcription repression [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
additional information
produce as 43 aa pro-peptide, secreted to the medium, and processed to the mature 6 aa AimX peptide that can be taken up by the cells again [pubmed|34562384]
Biological materials
Mutant
BKE20850 ([gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE20850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCTCACCTCCTTTAA, downstream forward: _UP4_TAAAATCCATTGACACATAA
BKK20850 ([gene|20735BFECA52826F0F4D55843EEE7798F414993C|aimP]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK20850 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCTCACCTCCTTTAA, downstream forward: _UP4_TAAAATCCATTGACACATAA
References
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Time of last update: 2024-04-22 17:34:17
Author of last update: Jstuelk