yhaM
168
RNase, 3 5 exoribonuclease
locus
BSU_09930
Molecular weight
35.53 kDa
pI
5.85
function
RNA degradation
product
RNase YhaM
essential
no
synonyms
yhaM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3481 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,069,042 1,069,986
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The protein
Catalyzed reaction/ biological activity
3'-5' exoribonuclease
Protein family
YhaM family (single member, according to UniProt)
[wiki|Domains]
[wiki|HD domain] (aa 163-297) (according to UniProt)
Structure
[AF|O07521]
[wiki|Localization]
cytoplasm (Homogeneous) [Pubmed|16479537]
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [Pubmed|17981983]
Expression and Regulation
Operons
genes
[gene|3E27C881BB3DE3FD55B7AD21B8771A859D80786F|yhaO]-[gene|709C4D0AE9C78C9A367F37B9C3B37D2516850D7C|sbcE]-[gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]
description
[Pubmed|16267290]
regulation
induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]) [Pubmed|16267290]
regulatory mechanism
[protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA]: repression, [Pubmed|16267290], in [regulon|protein:D267AF38B0CF107042326E9B8F3DD3C9C85840E4|lexA regulon]
Biological materials
Mutant
MGNA-B499 (yhaM::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1498 NBRP B. subtilis, Japan]
BKE09930 ([gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE09930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTAAAGCTCCCTC, downstream forward: _UP4_TAACTTAAAAAGGACTGATG
BKK09930 ([gene|6D585EB5E56A1E5C1C31680D960043BA08C817E2|yhaM]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK09930 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCTATTAAAGCTCCCTC, downstream forward: _UP4_TAACTTAAAAAGGACTGATG
labs
[wiki|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage]
References
Reviews
Original Publications
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Time of last update: 2024-04-19 17:04:42
Author of last update: Jstuelk