treA
168
phospho-alpha-glucosidase
locus
BSU_07810
Molecular weight
65.01 kDa
pI
4.89
function
trehalose utilization
product
phospho-alpha-glucosidase
essential
no
ec
3.2.1.93
synonyms
treA, treC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0366 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
851,850 853,535
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The protein
Catalyzed reaction/ biological activity
α,α-trehalose 6-phosphate + H2O --> D-glucose + D-glucose 6-phosphate (according to UniProt)
Protein family
[wiki|glycosyl hydrolase 13 family] (according to UniProt)
Structure
[PDB|5BRQ] (from B. licheniformis, 73% identity) [pubmed|26894535]
[AF|P39795]
Paralogous protein(s)
[protein|6E5AB4620F9A896C32CD77AF314C67035814AE0A|malL], [protein|A641BA91317CBCFE34A2BE69007247F209075095|ycdG], [protein|A9500B1E45CCE51F4A699E4A7BC1F6B272A25A86|yugT]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|BC568649A341B2E6341993EDA4BF52BDE18A3294|treP]-[gene|2EB9E0C492DF57DF683817E31D6DD34D7580E631|treA]-[gene|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR]
description
[Pubmed|8755887]
regulation
expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|21636651]
regulatory mechanism
[protein|DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR]: repression, [Pubmed|8755887], in [regulon|protein:DC374E280C5A67C138D7EAC43AA66DA63CEF82B6|treR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|18977770], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP]: activation, [Pubmed|21636651], in [regulon|protein:638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|phoP regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|8755887], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-C260 (treA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2258 NBRP B. subtilis, Japan]
GP1118 (spc), available in [wiki|Jörg Stülke]'s lab
BKE07810 ([gene|2EB9E0C492DF57DF683817E31D6DD34D7580E631|treA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTTTCCACCACCATA, downstream forward: _UP4_TAAACTAAGCTGGGTGGTCC
BKK07810 ([gene|2EB9E0C492DF57DF683817E31D6DD34D7580E631|treA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07810 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGTTTCCACCACCATA, downstream forward: _UP4_TAAACTAAGCTGGGTGGTCC
References
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Time of last update: 2024-04-18 20:42:24
Author of last update: Melvin.boenninger