thrB

thrB
168

homoserine kinase

locus
BSU_32240
Molecular weight
33.17 kDa
pI
4.74
Protein length
Gene length
function
biosynthesis of threonine
product
homoserine kinase
essential
no
ec
2.7.1.39
synonyms
thrB, thrA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0083 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,312,844  3,313,773
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The protein
Catalyzed reaction/ biological activity
ATP + L-homoserine --> ADP + H+ + O-phospho-L-homoserine (according to UniProt)
Protein family
GHMP kinase family (together with [protein|36930CC6FDFCA23D43E264FEA375B78A1434E1BD|galK] and [protein|8FA635D1915108BF29A864AF4DA28ECF633F735F|ispE]) (according to UniProt)
Structure
[PDB|3HUL] (from ''Listeria monocytogenes'', 41% identity, 61% similarity)
[AF|P04948]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|0F40291BB10DB6D7DFD94B9C7D700F4410C4EE69|yutH]-[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|22383849]
regulation
expressed during [wiki|sporulation] [Pubmed|22383849]
Open in new tab

[gene|0F40291BB10DB6D7DFD94B9C7D700F4410C4EE69|yutH]→[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]

2024-03-10 09:01:53

Jstuelk

78

679308b32ee019040de1f3917a024913a4a6e24e

A05F487B4319B2D895BE22D03C7D331712EA7165

genes
[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|12107147]
regulation
expressed in the presence of lysine or cysteine ([wiki|ThrR]) [Pubmed|27260660]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|24163341], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA]: repression, [Pubmed|25755103], in [regulon|protein:857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA regulon]
[protein|A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR]: repression, [Pubmed|27260660], in [regulon|protein:A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR regulon]
Open in new tab

[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]→[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]

2024-03-10 09:02:04

ghost

78

222d0d37f0abf96a1c1d52c80944e1ea90292f91

CF7B5B8FEE827A7467051420FCA74276BC912664

Biological materials
Mutant
BKE32240 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32240 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGAGAACAGCATGTCGGCTT,  downstream forward: _UP4_TAGATCATGCCAAGCGTTCC
BKK32240 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32240 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGAGAACAGCATGTCGGCTT,  downstream forward: _UP4_TAGATCATGCCAAGCGTTCC
BP1275 ([gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]::phleo trp+) available in [wiki|Jörg Stülke]'s & [wiki|Fabian Commichau]'s lab
References
12107147,3098560,24163341,27260660

290302BA8A4E44C62AE3071C1F7DE18B20605607

Page visits: 3431

Time of last update: 2024-03-28 10:06:32

Author of last update: Melvin.boenninger