spoIIGA
168
Pro-[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] protease
locus
BSU_15310
Molecular weight
34.70 kDa
pI
8.55
function
maturation of [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]
product
Pro-[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE] protease
essential
no
synonyms
spoIIGA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5818 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,603,779 1,604,708
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The protein
Protein family
peptidase U4 family (single member, according to UniProt)
Structure
[AF|P13801]
Effectors of protein activity
[protein|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA] protease activity is stimulated by the interaction with [protein|9F338225E1286D530EAAAB504DEC8D5AFA06AC8D|spoIIR] in the intermembrane space between the forespore and the mother cell [Pubmed|22111992]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA]-[gene|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]-[gene|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]
description
[Pubmed|1902213]
regulation
''[wiki|spoIIGA]'': expressed under conditions that trigger sporulation ([wiki|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8288522,15687200 PubMed]
regulatory mechanism
[protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR]: repression, in [regulon|protein:5A6FBAE6553343092862CB79E150F934978C32A9|sinR regulon]
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: activation, [PubMed|8288522,15687200], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2512576], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|1902213], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
additional information
the mRNA half-life is about 2.6 min [PubMed|24163345]
Biological materials
Mutant
BKE15310 ([gene|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE15310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATCTGACTCCTTTCTTT, downstream forward: _UP4_TAATGTTCGCAAATGTCCGT
BKK15310 ([gene|221829E084DA78ACE1C2DFCEB6E59EDA534FF55D|spoIIGA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK15310 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACATCTGACTCCTTTCTTT, downstream forward: _UP4_TAATGTTCGCAAATGTCCGT
References
Reviews
Original Publications
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Time of last update: 2024-04-18 17:44:29
Author of last update: Jstuelk