ppsE
168
plipastatin synthetase
locus
BSU_18300
Molecular weight
144.39 kDa
pI
5.66
function
production of the antibacterial compound plipastatin
product
plipastatin synthetase
essential
no
synonyms
ppsE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG3319 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,960,198 → 1,964,037
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The protein
Protein family
[wiki|ATP-dependent AMP-binding enzyme family] (according to UniProt)
[wiki|Domains]
[wiki|Carrier domain] (aa 975-1050) (according to UniProt)
Structure
[PDB|2VSQ] ([protein|1D5F227860A321506A1AB4BAE63CAD3A66E43BFC|srfAC], 40% identity) [pubmed|18583577]
[AF|O31827]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|E3D7EF8F165CAC2682B0D620081C5C6E555E43C4|ppsA]-[gene|E7A2F93B33B1899313893D362D92405232BC9097|ppsB]-[gene|D11CE89E2AC2ADE3FEFEC261E295EC5906CE6407|ppsC]-[gene|E73D9F1A8F54DAD4B2056CABBE580D7AD36CB042|ppsD]-[gene|C1C051209943E02369356075EAA733297E9478CB|ppsE]
description
[Pubmed|20817675]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
Biological materials
Mutant
BKE18300 (Δ[gene|C1C051209943E02369356075EAA733297E9478CB|ppsE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCTGCACCTTTCTTCACGG, downstream forward: _UP4_TAAAGCGGATTAGCGGACAG
BKK18300 (Δ[gene|C1C051209943E02369356075EAA733297E9478CB|ppsE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCTGCACCTTTCTTCACGG, downstream forward: _UP4_TAAAGCGGATTAGCGGACAG
References
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Time of last update: 2024-04-19 14:21:19
Author of last update: Melvin.boenninger