nrdR

nrdR
168

negative regulator of transcription of the ribonucleotide reductase nrd operon

locus
BSU_29000
Molecular weight
17.77 kDa
pI
8.05
Protein length
Gene length
function
control of ribonucleotide reductase expression
product
transcription repressor of the ribonucleotide reductase nrd operon
essential
no
synonyms
nrdR, ytcG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1327 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,965,681 → 2,966,139
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The protein
Protein family
nrdR family (single member, according to UniProt)
Structure
[PDB|7P37] (from Streptomyces coelicolor, ATP-loaded NrdR dodecamer, 46% identity) [pubmed|35577776]
[PDB|7P3F] (from Streptomyces coelicolor, dATP/ATP-loaded NrdR tetramer bound to its cognate DNA, 46% identity) [pubmed|35577776]
[PDB|7P3Q] (from Streptomyces coelicolor, dATP/ATP-loaded NrdR octamer, 46% identity) [pubmed|35577776]
[AF|Q45549]
Expression and Regulation
Operons
genes
[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]
description
[Pubmed|9387221]
regulation
constitutively expressed [Pubmed|27920297]
additional information
the terminator is [protein|search|NusA]-dependent [ http://www.nature.com/articles/nmicrobiol20157 Reference]
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[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]

2024-03-21 03:22:15

ghost

43

680621610d9ed4680b6a081323a1d7ab74b579b2

8C5D40DAC44F84C16DD332A53D1291EA0D43DB52

Biological materials
Mutant
MGNA-A123 (ytcG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/123 NBRP B. subtilis, Japan]
BKE29000 (Δ[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE29000 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATAAAATCAGCTCCCAAC,  downstream forward: _UP4_TAAAAGAGCTAAGAGGATTC
BKK29000 (Δ[gene|FD4E988BB73F6476CCEA4C521F343D6F8CBA457F|nrdR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK29000 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATAAAATCAGCTCCCAAC,  downstream forward: _UP4_TAAAAGAGCTAAGAGGATTC
References
16950922,9387221,15949864,27920297,28624879,35577776,36053906,36815589

FD4E988BB73F6476CCEA4C521F343D6F8CBA457F

Page visits: 3749

Time of last update: 2024-03-28 21:41:05

Author of last update: Jstuelk