mhqA
168
hydroquinone-specific dioxygenase, confers resistence to methyl-hydroxyquinone
locus
BSU_12870
Molecular weight
35.23 kDa
pI
5.4
function
resistence to methyl-hydroxyquinone
product
hydroquinone-specific dioxygenase
essential
no
synonyms
mhqA, ykcA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2514 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,353,080 1,354,030
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The protein
Protein family
[wiki|extradiol ring-cleavage dioxygenase family] (according to UniProt)
[wiki|Domains]
2 [wiki|VOC domain]s (aa 5-131, aa 154-278) (according to UniProt)
Structure
[PDB|3OAJ] ([protein|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO], 34% identical residues)
[AF|O34689]
Paralogous protein(s)
[protein|A1CB3DCF2EC78B9B0585CA6AC6F5BB37B8AF0208|mhqE], [protein|ACAFB2072E74CC059B492A31EF492028B96C569F|mhqO]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]
description
[Pubmed|17725564]
regulation
induced by catechol and 2-methylhydroquinone ([protein|search|MhqR]) [Pubmed|17725564]
regulatory mechanism
[protein|997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR]: repression, [Pubmed|17725564], in [regulon|protein:997B828A99D6D8460712C18ED0CE566B285C22DC|mhqR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17725564], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-A737 (ykcA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/737 NBRP B. subtilis, Japan]
BKE12870 ([gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE12870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGCTGTCCCTCCAGGT, downstream forward: _UP4_TAAATTGTGATTCTTTTGCC
BKK12870 ([gene|7334017333600B876030056BE9247AD4E8996A1D|mhqA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK12870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATGCTGTCCCTCCAGGT, downstream forward: _UP4_TAAATTGTGATTCTTTTGCC
References
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Time of last update: 2024-04-22 02:29:45
Author of last update: Melvin.boenninger