lytH
168
differentiation-associated peptidoglycan hydrolase involved in endospore cortex maturation
locus
BSU_32340
Molecular weight
39.48 kDa
pI
6.89
function
endospore cortex maturation
product
peptidoglycan hydrolase
essential
no
synonyms
lytH, yunA, yutA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0739 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,321,455 3,322,435
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The protein
Catalyzed reaction/ biological activity
cleaves the peptide bond between L-Ala (position 1 in the peptioglycan peptide) and D-Glu (position 2) [Pubmed|18266855]
Protein family
peptidase M23B family (single member, according to UniProt)
Structure
[PDB|3NYY] (from Ruminococcus gnavus, the C-terminal peptidase M23 domain, aa 178 ... 315, 46% identity)
[AF|O32130]
Expression and Regulation
Operons
genes
[gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]
description
[Pubmed|12813075]
regulation
expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|12813075]
sigma factors
[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK]: sigma factor, [Pubmed|12813075], in [regulon|protein:24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK regulon]
Biological materials
Mutant
MGNA-B579 (yunA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1578 NBRP B. subtilis, Japan]
BKE32340 ([gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAATAATCTCCTTTCA, downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
BKK32340 ([gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32340 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAAATAATCTCCTTTCA, downstream forward: _UP4_TAACAAAAAGCCGCCTCTTC
References
Reviews
Original Publications
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Time of last update: 2024-04-18 18:23:03
Author of last update: Jstuelk