kduD

kduD
168

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

locus
BSU_22140
Molecular weight
27.04 kDa
pI
6.5
Protein length
Gene length
function
utilization of galacturonic acid
essential
no
ec
1.1.1.125
synonyms
kduD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,326,683 → 2,327,447
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The protein
Catalyzed reaction/ biological activity
2-dehydro-3-deoxy-D-gluconate + NAD+ --> 3-deoxy-D-glycero-2,5-hexodiulosonate + H+ + NADH (according to UniProt)
Protein family
[wiki|Short-chain dehydrogenases/reductases (SDR) family] (according to UniProt)
Structure
[PDB|4HP8] (from Agrobacterium tumefaciens, 54% identity)
[AF|P50842]
Paralogous protein(s)
[protein|3161519994609DA9360ED6E073E4A4C8C6210EFB|ydaD], (36.7%)
[protein|6047F2493FCE3D2A9BDB1AD88E5926ECEED81036|yhxC], (33,6%)
[protein|B6FF689E65906186F3576B378650D713DB84EDDA|ycdF], (34.3%)
[protein|EAEEA4DD9641919830A81185333A2610B964D37C|yhdF], (33.1%)
Expression and Regulation
Operons
genes
[gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]-[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]
description
[Pubmed|17322190]
regulation
induced by galacturonate ([protein|search|KdgR]) [Pubmed|17322190]
regulatory mechanism
[protein|891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR]: repression, [Pubmed|17322190], in [regulon|protein:891A32A19D1353BA566FF121BBCA7B986D31D129|kdgR regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|17322190], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|17322190], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|CFAEF60AD73F18C8DB5EF042210602B149D51152|kduI]→[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]

2024-03-03 11:05:00

ghost

49

4a8739bc6783690fc74587a3d4541c259279a581

B77865E5AAA4E592F977DA1B986CD2525D071736

Biological materials
Mutant
BKE22140 (Δ[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AAAGGCGTCATGTAGATAAC,  downstream forward: _UP4_TGACAAATAAAAAAGCTGAC
BKK22140 (Δ[gene|FBBDE1E058223D5E8CEB07CAA50940A329C809E4|kduD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AAAGGCGTCATGTAGATAAC,  downstream forward: _UP4_TGACAAATAAAAAAGCTGAC
References
17322190

FBBDE1E058223D5E8CEB07CAA50940A329C809E4

Page visits: 1531

Time of last update: 2024-03-27 13:06:01

Author of last update: Melvin.boenninger