hmoA

hmoA
168

heme monooxygenase

locus
BSU_07150
Molecular weight
14.57 kDa
pI
9.13
Protein length
Gene length
function
degradation of heme
product
heme monooxygenase
essential
no
synonyms
hmoA, yetG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2329 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
785,113  785,490
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
binds hemin ''in vitro'' with ~1:1 stoichiometry and degrades hemin in the presence of an electron donor [Pubmed|21873409]
heme b + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] --> biliverdin IXα + CO + Fe2+  + H+ + 3 H2O + 3 oxidized [NADPH—hemoprotein reductase] (according to UniProt)
Protein family
antibiotic biosynthesis monooxygenase family (with [protein|4EE1809AC405170A78F6F8C8C02EEF5CC54DE076|hmoB], according to UniProt)
[wiki|Domains]
[wiki|ABM domain] (aa 2-95) (according to UniProt)
Structure
[PDB|1TZ0] (from [gene|search|B. cereus], 57% identity)
[AF|O31534]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]
description
(based on genomic context) null
regulation
induced by iron limitation ([protein|search|Fur]) [Pubmed|21873409]
regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur]: repression, [Pubmed|21873409], in [regulon|protein:F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|fur regulon]
Open in new tab

[gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]

2024-03-11 04:18:27

ghost

40

0c7b16a020c2e8024e4ff7fa52d23836a7c6f3b8

E651851DF1274BBDC6F7E91633D91E05982D6F42

Biological materials
Mutant
MGNA-B458 (yetG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1457 NBRP B. subtilis, Japan]
BKE07150 ([gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE07150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGTCTCACTCCAATCA,  downstream forward: _UP4_TAAAAAGCTTGCGCCTTGCT
BKK07150 ([gene|A4E1A1FA886980C863919DA011AC1EEDDBD74967|hmoA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK07150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTGTCTCACTCCAATCA,  downstream forward: _UP4_TAAAAAGCTTGCGCCTTGCT
References
37198628

A4E1A1FA886980C863919DA011AC1EEDDBD74967

Page visits: 2065

Time of last update: 2024-03-27 21:33:08

Author of last update: Jstuelk