guaD

guaD
168

guanine deaminase, general stress protein, important for survival of ethanol and paraquat stresses

locus
BSU_13170
Molecular weight
17.01 kDa
pI
5
Protein length
Gene length
function
deamination of guanine to xanthine, purine salvage and interconversion
product
guanine deaminase
essential
no
ec
3.5.4.3
synonyms
guaD, gde, yknA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0590 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,382,677 → 1,383,147
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The protein
Catalyzed reaction/ biological activity
guanine + H+ + H2O --> NH4+ + xanthine (according to UniProt)
Protein family
[wiki|Cytidine and deoxycytidylate deaminase family] (according to UniProt)
[wiki|Domains]
[wiki|CMP/dCMP-type deaminase domain] (aa 1-132) (according to UniProt)
Structure
[PDB|1WKQ]
[AF|O34598]
Expression and Regulation
Operons
genes
[gene|AEEC5CAC20D3A182074332087FD3CDCCF05F28CC|guaD]
description
[Pubmed|11101664]
regulation
induced by stress ([protein|search|SigB]) [Pubmed|15805528]
regulatory mechanism
[protein|52C1601482C26400A524E880334BB801F832D6ED|pucR]: activation, [Pubmed|12029039], in [regulon|protein:52C1601482C26400A524E880334BB801F832D6ED|pucR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|11101664], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|15805528], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
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[gene|AEEC5CAC20D3A182074332087FD3CDCCF05F28CC|guaD]

2024-01-22 03:01:24

ghost

32

42512af819f887b390b78a35b593e9528ad64328

00E1BB001F9BFC50BC1BFED748FEFE960390C414

Biological materials
Mutant
MGNA-A752 (yknA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/752 NBRP B. subtilis, Japan]
BKE13170 (Δ[gene|AEEC5CAC20D3A182074332087FD3CDCCF05F28CC|guaD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE13170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCCCAATCCCTCCTGTCA,  downstream forward: _UP4_TAAAAGGATCAGGCATGCGC
BKK13170 (Δ[gene|AEEC5CAC20D3A182074332087FD3CDCCF05F28CC|guaD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK13170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCCCAATCCCTCCTGTCA,  downstream forward: _UP4_TAAAAGGATCAGGCATGCGC
References
11101664,12029039,15180998,15805528,11344136,22582280

AEEC5CAC20D3A182074332087FD3CDCCF05F28CC

Page visits: 5380

Time of last update: 2024-03-29 05:33:34

Author of last update: TPed