gerKB

gerKB
168

nutrient receptor

locus
BSU_03720
Molecular weight
41.61 kDa
pI
8.92
Protein length
Gene length
function
germination
product
part of the putative nutrient-gated [protein|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]-[protein|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC] ion channel
essential
no
synonyms
gerKB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5902 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
422,982 → 424,103
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
the [protein|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[protein|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]-[protein|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC] ion channel likely releases ions from the spore core in response to asparagine, glucose, fructose and K+ to trigger [category|SW.4.2.4|Germination], this requires the gerB locus [pubmed|37104613]
Protein family
[wiki|amino acid-polyamine-organocation (APC) superfamily] (according to UniProt)
[wiki|Spore germination protein (SGP) (TC 2.A.3.9) family] (according to UniProt)
Structure
[AF|P49940]
Paralogous protein(s)
[protein|D70EC7C02BC79BED724489ABCB6356447F215B87|gerBB], [protein|5FF739B8C087207039BB6DC293EE77F59337ED0B|gerAB], [protein|B14179D0EF5D3493E5CDB8E15378A5088B4FFD10|yndE]
[wiki|Localization]
spore inner membrane [Pubmed|21696470]
Expression and Regulation
Operons
genes
[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]-[gene|D5D4E1E182F972BEF6BB432A7FF25EF45F1F0D95|gerKC]-[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]
description
[pubmed|22383849]
regulation
expressed during sporulation ([protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG], [wiki|SpoVT]) [Pubmed|16707705]
regulatory mechanism
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT]: repression, [Pubmed|16707705], in [regulon|protein:01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT regulon]
sigma factors
[protein|5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG]: sigma factor, [Pubmed|16707705], in [regulon|protein:5F24258282F3166B7696B9E9ABC1706E4D06C944|sigG regulon]
additional information
700 molecules are present per spore [PubMed|23749970]
Open in new tab

[gene|EDB2F4C132211F01654F2A2ED3D220EC15CE6F22|gerKA]→[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]

2024-03-20 14:49:58

Jstuelk

45

2621476d83b6d6d9772912d035f86d1791de6cd2

5744A84AC240BED93491E29AB72B18EEE120A73F

Biological materials
Mutant
BKE03720 (Δ[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03720 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC,  downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA
BKK03720 (Δ[gene|D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA|gerKB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03720 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTGTCACTTCCCCTTTC,  downstream forward: _UP4_TGATAAAAAGAGCGGGGGGA
References
36815589,16707705,21696470,16352818,23396907,26731423,32210351,37104613

D1AFCB1BE693AB6B8461B7764B6641E6EB1404FA

Page visits: 2834

Time of last update: 2024-03-28 06:29:00

Author of last update: Jstuelk