fra

fra
168

frataxin-like protein, required for the biosynthesis of iron-sulfur clusters, intracellular carrier to provide iron for the ferrochelatase HemH

locus
BSU_05750
Molecular weight
14.28 kDa
pI
5.38
Protein length
Gene length
function
intracellular iron channeling, biosynthesis of iron-sulfur clusters
product
frataxin-like protein
essential
no
synonyms
fra, ydhG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5646 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
621,847  622,218
Phenotypes of a mutant
severe growth phenotype associated with a broadly disturbed iron homeostasis [Pubmed|21744456]
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The protein
Catalyzed reaction/ biological activity
transfers iron onto the B. subtilis SUF system ([protein|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|sufU]-[protein|88ACE6B79534338F7C72F107B35A0B2384007088|sufS]) for iron-sulfur cluster biosynthesis [Pubmed|21744456]
[wiki|Cofactors]
Fe(2+) is bound with high affinity [Pubmed|20087498]
Structure
[PDB|2OC6]
[AF|Q797E6]
Expression and Regulation
Operons
genes
[gene|188833286AD73DF7730954D47BD676D8137679E9|fra]
description
[Pubmed|22383849]
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[gene|188833286AD73DF7730954D47BD676D8137679E9|fra]

2024-03-14 21:10:00

Jstuelk

31

1509a96b8b2d3a18c376d79c8d4f288119b8579d

3F54E456AA08C6AB3C61146E34D3781C04F678DF

Biological materials
Mutant
MGNA-C182 (ydhG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2180 NBRP B. subtilis, Japan]
available in [wiki|Mohamed Marahiel]'s lab
BKE05750 ([gene|188833286AD73DF7730954D47BD676D8137679E9|fra]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05750 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTTCCCTCCTAAAA,  downstream forward: _UP4_TGAAGAAAAAGGCATAACAT
BKK05750 ([gene|188833286AD73DF7730954D47BD676D8137679E9|fra]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05750 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTTCCCTCCTAAAA,  downstream forward: _UP4_TGAAGAAAAAGGCATAACAT
References
Reviews
37593721
Original Publications
20087498,21744456,25826316,27382962

188833286AD73DF7730954D47BD676D8137679E9

Page visits: 2990

Time of last update: 2024-03-29 02:34:22

Author of last update: Jstuelk