folC
168
folyl-polyglutamate synthetase
locus
BSU_28080
Molecular weight
48.00 kDa
pI
5.81
function
biosynthesis of folate
product
folyl-polyglutamate synthetase
essential
yes
ec
6.3.2.17
synonyms
folC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0285 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,865,312 2,866,604
Phenotypes of a mutant
essential [Pubmed|28189581]
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The protein
Catalyzed reaction/ biological activity
7,8-dihydropteroate + ATP + L-glutamate --> 7,8-dihydrofolate + ADP + H+ + phosphate (according to UniProt)
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)n + ATP + L-glutamate --> (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)n+1 + ADP + H+ + phosphate (according to UniProt)
Protein family
Folylpolyglutamate synthase family (single member, according to UniProt)
Structure
[PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466]
[AF|Q05865]
[wiki|Localization]
cytoplasm (according to UniProt)
Expression and Regulation
Operons
genes
[gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
description
[Pubmed|9098041]
regulation
induced by valine limitation ([wiki|T-box]) [Pubmed|9098041,19258532]
the [wiki|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
regulatory mechanism
T-box: RNA switch, via [wiki|riboswitch], in [regulon|other_regulator:T-box|T-box]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9098041], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
References
Reviews
Original Publications
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Time of last update: 2024-04-16 01:54:45
Author of last update: Melvin.boenninger