dnaC

dnaC
168

replicative DNA helicase, part of the [wiki|replisome]

locus
BSU_40440
Molecular weight
50.44 kDa
pI
4.55
Protein length
Gene length
function
[category|SW.3.1.1|DNA replication]
product
replicative DNA helicase
essential
yes
ec
3.6.4.12
synonyms
dnaC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0305 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,157,471  4,158,835
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
stimulates [protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|dnaG] primase activity [Pubmed|23563155]
ATP + H2O --> ADP + H+ + phosphate (according to UniProt)
Protein family
[wiki|helicase family] (according to UniProt)
[wiki|Domains]
SF4 helicase domain (aa 179-445) (according to UniProt)
Structure
[PDB|2R6A] (Geobacillus stearothermophilus),  [PDB|2R6C],  [PDB|2R6D],  [PDB|2R6E]
[PDB|4M4W] (the [protein|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]-[protein|AC1B507C6B1640E9BEA1F9F01628120F3680C976|dnaI]-[protein|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|dnaG] complex) [Pubmed|24048025]
[AF|P37469]
[wiki|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]
description
[pubmed|22383849]
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[gene|5CF09E089AA70A32F640CE0D33D1F05312AAE24D|dnaC]

2024-03-14 11:08:56

Jstuelk

68

906bab1114ce00b46ea2c1916f84c3837d66e033

881BC4E03C4BDAB2BA84327CDCA65C9E67548D2F

Biological materials
two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Fabian Commichau]'s lab
References
Reviews
22797751,28075389,36877032
Original Publications
10844689,12718886,11250911,20122408,16479537,10844689,19744498,19968790,12060778,23525462,23563155,24048025,30285297,33504660,36053906

5CF09E089AA70A32F640CE0D33D1F05312AAE24D

Page visits: 5862

Time of last update: 2024-03-26 06:00:50

Author of last update: Jstuelk