cca

cca
168

tRNA nucleotidyltransferase, maturation of the single-copy tRNACys, which lacks an encoded CCA 3 end

locus
BSU_22450
Molecular weight
45.29 kDa
pI
8.04
Protein length
Gene length
function
tRNA modification
product
tRNA nucleotidyltransferase
essential
yes
ec
2.7.7.25
synonyms
cca, papS, ypjI

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0617 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,355,880  2,357,073
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
tRNA precursor + ATP + 2 CTP --> tRNA with 3' CCA end + 3 diphosphate (according to UniProt)
Protein family
tRNA nucleotidyltransferase/poly(A) polymerase family (single member, according to UniProt)
the protein is similar to the ''E. coli'' poly(A) polymerase
Structure
[PDB|1MIV] (Geobacillus stearothermophilus 44% identity)
[AF|P42977]
Expression and Regulation
Operons
genes
[gene|A828298EA2A002538876FBA6113648AAD9C4C317|ypjD]-[gene|5AB90032031653A913E15B26B3E1AE246E95AABF|dapB]-[gene|341F198B2BD4261B20C00181D084A7C5E33E39B3|mgsA]-[gene|60367F0396612C8A6491FD92A73B30BED7215506|bshB1]-[gene|187C78441816FC74B0FCCE34997E8AEC0A80B114|bshA]-[gene|4C4FA59FF5D100E941EF470C0C54E85681ADC74F|cca]-[gene|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]
description
[Pubmed|20308541]
regulation
induced by diamide stess (thiol depletion) ([protein|search|Spx]) [Pubmed|23894131]
regulatory mechanism
[protein|2C6386E9A63F410558D168798D077DF91590F454|spx]: activation, [Pubmed|23894131], in [regulon|protein:2C6386E9A63F410558D168798D077DF91590F454|spx regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|23894131], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|A828298EA2A002538876FBA6113648AAD9C4C317|ypjD]→[gene|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]

2024-01-29 08:50:51

ghost

48

53bf67b167bd77fe013a5e22a2f6ddcbf0c547e2

73042872A92944881DD9D94DF293F1857E4735FB

References
Reviews
19883645,16364630,20155482,18523015,28117687
Original Publications
17179213,12526808,20360175,9829937,16109934,31041723
Operon and expression
20308541,23894131

4C4FA59FF5D100E941EF470C0C54E85681ADC74F

Page visits: 1969

Time of last update: 2024-03-28 16:03:27

Author of last update: Melvin.boenninger