bioD

bioD
168

dethiobiotin synthase

locus
BSU_30210
Molecular weight
25.01 kDa
pI
6.21
Protein length
Gene length
function
biosynthesis of biotin
product
dethiobiotin synthase
essential
no
ec
6.3.3.3
synonyms
bioD

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,091,492 → 3,092,187
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The protein
Catalyzed reaction/ biological activity
7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 3 H+ + phosphate (according to UniProt)
Protein family
dethiobiotin synthetase family (single member, according to UniProt)
Structure
[PDB|1DTS] (from E. coli, 32% identity) [pubmed|8081756]
[AF|P53558]
Expression and Regulation
Operons
genes
[gene|C40116089BAD3F9831F8C837DC4F2E045753ABDE|bioW]-[gene|68C86FED3575B864C576DFB73FE7B5BF83994D1F|bioA]-[gene|8B6A3E86A88928526D94FDA94B9C81ABF6E9ACFB|bioF]-[gene|D9A71DAF949FB6C9C22C8361D83C5A0741184977|bioD]-[gene|5880617EB95FC0D19219A868D6D0A3D1D0D9C532|bioB]-[gene|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|bioI]-[gene|089A32D08B5A7E552CBD9CB9745BD542863B4558|ytbQ]
description
[Pubmed|8763940,8892842]
regulation
repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]
regulatory mechanism
[protein|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA]: repression, [Pubmed|8763940,8892842], in [regulon|protein:F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|birA regulon]
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[gene|C40116089BAD3F9831F8C837DC4F2E045753ABDE|bioW]→[gene|089A32D08B5A7E552CBD9CB9745BD542863B4558|ytbQ]

2024-01-26 03:39:45

ghost

41

8e74711c48d33750c45114afa6e28dd08cdf4ea5

F7255B320407AE19B7B38F8E863B5EF4A9BF3D52

Biological materials
Mutant
BKE30210 (Δ[gene|D9A71DAF949FB6C9C22C8361D83C5A0741184977|bioD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE30210 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC,  downstream forward: _UP4_ATGAATCAAGTGGGGGTATG
BKK30210 (Δ[gene|D9A71DAF949FB6C9C22C8361D83C5A0741184977|bioD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK30210 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGTTCCCGTCACAAAAAAAC,  downstream forward: _UP4_ATGAATCAAGTGGGGGTATG
References
Reviews
21437340
Original Publications
8763940,8892842,8081756

D9A71DAF949FB6C9C22C8361D83C5A0741184977

Page visits: 4998

Time of last update: 2024-03-26 16:48:51

Author of last update: Melvin.boenninger