adhA
168
thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins
locus
BSU_27010
Molecular weight
37.67 kDa
pI
5.37
function
response to toxic formaldehyde
product
thiol-dependent aldehyde dehydrogenase, reduction of aldehydes
essential
no
synonyms
adhA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1064 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,756,312 2,757,361
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The protein
Protein family
[wiki|zinc-containing alcohol dehydrogenase family] (according to UniProt)
Structure
[PDB|1UUF] (from E. coli, 54% identity)
[AF|C0SPA5]
Expression and Regulation
Operons
genes
[gene|BEF882B7B846E3B8BF4C08FBF0DBB9F5A2CA2604|yrzP]-[gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]-[gene|0960F1856A81237DBA6AF1FAF36172A63ECBE2D5|yraA]
description
[Pubmed|22383849]
genes
[gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]-[gene|0960F1856A81237DBA6AF1FAF36172A63ECBE2D5|yraA]
description
[Pubmed|19170879]
regulation
''[protein|search|adhA]'': induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde ([protein|search|AdhR]) [Pubmed|19170879]
regulatory mechanism
[protein|B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR]: activation, [Pubmed|19170879], in [regulon|protein:B24BA6ABCAF7325EC5F8B2655CA182FFC23395FD|adhR regulon]
Biological materials
Mutant
MGNA-A260 (adhA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/260 NBRP B. subtilis, Japan]
BKE27010 ([gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACGAACCTATCCTTTCT, downstream forward: _UP4_TAATAGGTTAGTCCTTATAT
BKK27010 ([gene|352544F3E79943E94E28A6EB5F4C543B529A02D1|adhA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACGAACCTATCCTTTCT, downstream forward: _UP4_TAATAGGTTAGTCCTTATAT
References
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Time of last update: 2024-04-19 12:50:22
Author of last update: Jstuelk