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Categories containing this gene/protein


phosphotransferase systems, utilization of specific carbon sources, phosphoproteins

This gene is a member of the following regulons


MtlR regulon

Gene


  • Coordinates on the chromosome (coding sequence): 451,185 -> 451,616
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

    Localization

    Interactions

  • PtsH-MtlF PubMed
  • MtlA-MtlF PubMed
  • MtlF-MtlR PubMed
  • Additional information

    Expression and Regulation


    Operon

  • mtlA-mtlF-mtlD PubMed
  • Sigma factor

    Regulation

  • induced by mannitol (MtlR) PubMed
  • repressed by glucose (MtlR) PubMed
  • Regulatory mechanism

  • MtlR: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Joyet P, Derkaoui M, Poncet S, Deutscher J

    Control of Bacillus subtilis mtl operon expression by complex phosphorylation-dependent regulation of the transcriptional activator MtlR

    Mol Microbiol. 2010 Jun 1;76(5):1279-94. doi: 10.1111/j.1365-2958.2010.07175.x. Epub 2010 May 4. PubMed PMID: 20444094.
    Watanabe S, Hamano M, Kakeshita H, Bunai K, Tojo S, Yamaguchi H, Fujita Y, Wong SL, Yamane K

    Mannitol-1-phosphate dehydrogenase (MtlD) is required for mannitol and glucitol assimilation in Bacillus subtilis: possible cooperation of mtl and gut operons

    J Bacteriol. 2003 Aug;185(16):4816-24. PubMed PMID: 12897001; PubMed Central PMCID: PMC166460.
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