It will happen very soon:
International Conference on Bacilli and Gram-positive bacteria
June 11 - 15, 2017, Berlin, Germany
Check out the program here
Dear users of SubtiWiki,
We have scheduled the server update on Sunday, 28th May, 2017. The website might be unreachable for a few hours. We appologize for the inconvinience and thank you for your understanding.
We will also use the time to upgrade SubtiWiki to a new version. It is current avaible online. Have a preview at Here
In the coming Bacilli meeting in Berlin, we will be hosting a SubtiWiki workshop, where we will reveal all nnew features as well as the strategies used behind the scene. We sincerely welcomme you to join.
Thank you for your understanding and support.
Your SubtiWiki Team
Categories containing this gene/protein
phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins
This gene is a member of the following regulons
Coordinates on the chromosome (coding sequence): 1,509,256 -> 1,511,163
Catalyzed reaction/ biological activityProtein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
Protein familyPTS permease, fructose/ mannitol permease (Fru) family PubMed
Effectors of protein activity
Structure2R4Q (EIIB domain)cell membrane (homogeneous) PubMedFruA-HPrFruA is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
Expression and Regulation
OperonfruR-fruK-fruA (according to DBTBS)
Regulationinduced in the presence of fructose (FruR) (according to DBTBS)
Regulatory mechanismFruR: transcription repression (according to DBTBS)
Labs working on this gene/protein
Marchadier E, Carballido-López R, Brinster S, Fabret C, Mervelet P, Bessières
P, Noirot-Gros MF, Fromion V, Noirot P
An expanded protein-protein interaction
network in Bacillus subtilis reveals a group of hubs: Exploration by an
integrative approach Proteomics. 2011 Aug;11(15):2981-91. doi:
10.1002/pmic.201000791. Epub 2011 May 31. PubMed PMID: 21630458.
Meile JC, Wu LJ, Ehrlich SD, Errington J, Noirot P
Systematic localisation of
proteins fused to the green fluorescent protein in Bacillus subtilis:
identification of new proteins at the DNA replication factory Proteomics. 2006
Apr;6(7):2135-46. PubMed PMID: 16479537.
Reizer J, Bachem S, Reizer A, Arnaud M, Saier MH Jr, Stülke J
phosphotransferase system genes revealed by genome analysis - the complete
complement of PTS proteins encoded within the genome of Bacillus subtilis
Microbiology. 1999 Dec;145 ( Pt 12):3419-29. PubMed PMID: 10627040.