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Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

FruR regulon


  • Coordinates on the chromosome (coding sequence): 1,509,256 -> 1,511,163
  • The protein

    Catalyzed reaction/ biological activity

  • Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)
  • Protein family

  • PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s)

  • ManP
  • Kinetic information




    Effectors of protein activity


  • 2R4Q (EIIB domain)
  • Localization

  • cell membrane (homogeneous) PubMed
  • Interactions

  • FruA-HPr
  • FruA is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
  • Additional information

    Expression and Regulation


  • fruR-fruK-fruA (according to DBTBS)
  • Sigma factor


  • induced in the presence of fructose (FruR) (according to DBTBS)
  • Regulatory mechanism

  • FruR: transcription repression (according to DBTBS)
  • Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Marchadier E, Carballido-López R, Brinster S, Fabret C, Mervelet P, Bessières P, Noirot-Gros MF, Fromion V, Noirot P

    An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach

    Proteomics. 2011 Aug;11(15):2981-91. doi: 10.1002/pmic.201000791. Epub 2011 May 31. PubMed PMID: 21630458.
    Meile JC, Wu LJ, Ehrlich SD, Errington J, Noirot P

    Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory

    Proteomics. 2006 Apr;6(7):2135-46. PubMed PMID: 16479537.
    Reizer J, Bachem S, Reizer A, Arnaud M, Saier MH Jr, Stülke J

    Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis

    Microbiology. 1999 Dec;145 ( Pt 12):3419-29. PubMed PMID: 10627040.
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